My son has IgA Nephropathy (stage 3b brought down from stage 4) and is currently on a conservative treatment (Losartan and a direutic) plan that has significantly brought down his proteinuria and hematuria (trace). My concern is if he should be taking any other medicines that directly treat his condition. I read that with stage 4 (egfr less than 30) no additional treatments are given but now that he has been in stage 3 for nearly a year should he be getting any additional treatments?. I recently read about the completion of a clinical trial for Rituximab for progressive IGAN. Is this drug now available for treatment for IGAN? Or are there any other treatment options in addition to the blood pressure medicines that he is currently on. Many thanks.

Rituximab (Rituxan) is not approved by the Food and Drug Administration (FDA) for the treatment of IgA nephropathy.  There have been many treatments proposed for IgA nephropathy, but no specific treatment has shown remarkable success.  Hence, it is best that your son consult with his nephrologist about management.  There is no difference in the management of IgA nephropathy between Stage 3 or Stage 4 chronic kidney disease (CKD).  His current management appears to be successful. I suggest that he continue to consult with his nephrologist.



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