What’s the general allopurinol dose given for each CKD stage?

Allopurinol is a medication used to treat gout.  The dose of allopurinol should be sufficient to lower the blood uric acid level so as to prevent attacks of gout.  In general, the goal is to get the blood uric acid level less than 6.0 milligrams per deciliter (mg/dl).  The lowest dose of allopurinol should be used to achieve control of gout.  Patients who have reduced kidney function may need a lower dose of allopurinol, but the specific dose is not based on kidney function but rather on achieving control of gout.  There have been some efforts to dictate a specific dose for allopurinol based on kidney function, but I do not subscribe to this philosophy.  The goal should be to prevent gout but use the lowest dose necessary to achieve the goal.

 

 

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