The goal of treating IgA Nephropathy is to lower the protein in the urine and improve kidney function. It sounds like your mother is being treated appropriately. Your mother’s physician should be monitoring the side effects of prednisolone. The side effects might include weight gain, diabetes, high blood pressure and thinning of the bones. These must be monitored by her physician. I suggest that you discuss the monitoring of prednisolone therapy with your mother’s physician. I am not sure why the calcitriol is being used, but it could be to protect her bones while she is taking the prednisolone.