There are no treatments to increase the glomerular filtration rate (GFR). Decreasing GFR is the result of chronic kidney disease (CKD) that destroys the small filters of the kidney known as glomeruli. Once those small filter are destroyed, they cannot be recovered. An estimated glomerular filtration rate (eGFR) of 22.7 milliliters per minute per 1.73 meters squared is Stage 4 CKD. The goal of treatment of CKD is to slow loss of kidney function and slow the loss of GFR. Treatments may transiently increase the GFR but permanent increase in the GFR is unlikely.