Hi, the patient has pain on her back, got done many tests and finally went for biopsy test, below is the test report. The doctor said nothing to worry just control blood pressure and stress and use less salt in food. But I consulted few other doctors, they said it is benign condition and can lead to kidney disease after 10 or 20 years but it is rare. It is a chronic kidney condition and has no treatment. Maybe after 20yrs, if unlucky can lead to end stage kidney disease. Another doctor says might the kidney have only 10yrs of life. Histopathology Report Clinical Data: Patient has microscopic hematuria, Negative family history. Specimen: A Light microscopy in formaldehyde. B. immunofluorescence in Michel’s medium. Diagnosis: IgA nephropathy with mesangial proliferation. Oxford classification score (M1E0SIT0). Interstitial fibrosis and tubular atrophy constitutes 20% No activity and mild chronicity Description: H&E, PAS, and trichrome stains. The biopsy consists of renal cortex containing 10 glomeruli. Seven glomeruli show segmental mesangial hypercelluarity (M1), without endocapillary proliferative lesion ( no celluar cresentsand no fibrinoid necrosis) (E0). Segmental sclerosis and adhesions to Bowmans capsule is seen in one glomerulus. (S1), no globally sclerotic glomeruli is seen. Thrichrome stains demonstrate segmental small mesangial red deposits. Blood vessels show mild degree of arteriolosclerosis. Interstitial fibrosis and tubular atrophy involves 20%of the cortex (T0) Immunofluorescence Microscopy (IF): Insufficien, renal medulla only. If stain performed on paraffin embedded tissue and show a cortex with 7 glomeruli. IgG: Glomeruli, negative. Tubules, 1+protein resorption droplets. IgA: Glomeruli 3+ granular mesangial staining. Tubules, negative, IgM: Glomeruli negative, Tubules, negative. C3: Glomeruli negative. Tubule: negative. C1q: Glomeruli, negative Patient Details : Female 26. Please give a Good Opinion on this report. I’m so confused and lot worried.

IgA nephropathy is a relatively common type of glomerulonephritis and has a variable course.  Some patients have only blood in the urine.  Others have protein and blood in the urine.  I am unable to give a prognosis without performing a complete history and physical examination.  You can go to our web site and learn more about IgA nephropathy at:  https://www.kidney.org/atoz/content/iganeph

 

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