I am 70 and have mccRCC and only about 2/3 of a kidney remaining. My creatinine runs about 2.4 to 2.9 (gfr around 16-19). I also have severe spinal stenosis with leg muscle spasms, particularly at night, causing lack of sleep. I was prescribed tizanidine (2 mg before bed), but on checking online information find that it is cleared through the kidney. Recommended cautions in patients with Chronic Kidney Disease.

I suggest that you consult with your physician and ask if the dosing of the tizanidine is proper for your level of kidney function.  The tizanidine dose may have to be adjusted for you kidney disease.

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