I’m very concerned for my husband. He’s a veteran, 40 years old, he was diagnosed with PKD in 2005 while in service with a few cysts on both kidneys, liver and pancreas with no other symptoms (pain, hematuria, limitations). In 12 years, it quickly progressed to stage 3, his liver is in very bad shape with cysts inside and out. His kidneys are 3x the normal size and littered with kidney stones up to 10mm. His ureters are covered inside and out with cysts. Our doctor has told us he will likely not live to see 60. We also just found out that the VA should not have prescribed him ibuprofen for his pain, 800 mg every 6 hrs everyday for 3 years. My question, is the ibuprofen at fault for causing his PKD to progress this fast or can PKD get this bad this quickly?

The long term use of ibuprofen has been associated with more rapid progression of chronic kidney disease (CKD).  Short term use (several weeks) is usually reversible and kidney function should return to baseline if the ibuprofen is stopped.  Your husband should avoid all non-steroidal anti-inflammatory drugs (NSAID’s) such as ibuprofen, Advil, Motrin, Aleve, Naproxen, and Naprosyn.


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