Hello, I have been recently diagnosed with F.S.G.S. My Doctor is always very positive about everything avoiding straightforward answers (which is common in my side of the world). Protein in the urine has become 1700 mg / l (24 hour test) Creatinine has become 1.4. Both figures are more than few months ago. How can I understand better my FSGS stage? Are these figures indicative and relevant? Is there any particular way to know the progress (I mean deterioration) of my health situation (disease)?

Focal segmental glomerulosclerosis (FSGS) is a scarring disease of the kidney. There are many causes but treatments have not been very effective. The diagnosis is based on findings on a kidney biopsy and there are at least six different classifications of the disease. Some of the classifications are associated with a better response to treatment than others. The relevant and important things to monitor are the serum creatinine and the estimated glomerular filtration rate (eGFR). The amount of protein in the urine is also a barometer of the disease. Most people are treated with an ACE-inhibitor or an ARB agent. Prednisone is often tried and there are many other agents that are often tried to avoid deterioration in the eGFR and hopefully reduce the protein in the urine (proteinuria).

In cases of kidney failure, this disease can also recur in a kidney transplant. Hence, it is a very difficult disease to manage.

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