I am a healthy, normal weight, non-diabetic, 31 year old Caucasian female. I have had bloodwork done 3 different times over the course of 2 years and my creatinine is consistently over 1.2 mg/dL and my eGFR is consistently under 60 mL/min/1.73m2. I was recently told the reason could be that I am on the oral contraceptive Ocella, which contains the hormone Drospirenone which has antimineralocorticoid activity and can act as a diuretic. However, the person who told me this, is not a physician. Is it possible for consistent abnormal lab work to be caused by Drospirenone or is that unlikely?

I am not aware of any diuretic activity for drospirenone. Drospirenone is a progestin-like compound and can have some anti-mineralocorticoid activity, but this would cause fluid retention and not diuresis. I am not able to provide any other diagnosis based on the information that you provide.

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