I am a healthy 35-year-old woman with normal blood pressure, not obese, 5’10”, active, not an amputee, not a bodybuilder and I don’t take protein supplements. Ten months ago during routine bloodwork, they found my GFR to be 68. A nephrologist had me do a 24 urine catch, and I don’t know the numbers, but they said my kidneys were functioning in a normal range. He chalked up the low GFR to me being tall. Two weeks ago during routine bloodwork it was down to 53. My creatinine is at 1.2. I called the nephrologist’s office and the nurse pretty much blew it off. It seems like a big drop and a low number for someone my age anyway. Should I be concerned?

I am unable to make a specific diagnosis based on the information that you present.  A drop in the estimated glomerular filtration rate (eGFR) from 68 milliliters per minute per 1.73 meters squared to 53 would be a significant drop.  The 24 hour urine collection that you mention, if done carefully and properly should be more accurate.  I do suggest that you also have urine testing for blood, protein and infection in order to complete the screening for chronic kidney disease (CKD).  I would also suggest repeating the blood test to check for laboratory inconsistency as a cause of the sudden fall in the eGFR.


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