Category Archives: Clinical Trials/Studies

Hello, I am concerned that the doctor said my dad needs dialysis because of high creatinine level or something. He asked if stem cell surgery is available in Australia or anywhere in the world? Sorry for my basic and amateur language I am just a young boy concerned for his health. Any answer will be appreciated. Thanks.

There are no stem cell therapies that are currently approved by the Food and Drug Administration (FDA) here in the United States. I am not aware of any stem cell therapy that has been shown to be successful in scientific … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Clinical Trials/Studies, Kidney-Related Health Questions, Nephrotic Syndrome

Have there been any studies to indicate that stem cell therapy has provided any help in delaying the need for dialysis for people with later stages of kidney disease? Thank You.

There are currently no stem cell treatments that have been approved by the Food and Drug Administration (FDA) for acute or chronic kidney disease (CKD). There is ongoing research into stem cell treatments for patients with CKD. You can go … Continue reading

Posted in Acute Kidney Injury, Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, Clinical Trials/Studies, Kidney-Related Health Questions

Ninety-seven patients (mean age, 48 years) with chronic renal failure (serum creatinine > 5 mg/dl), with a history of declining renal function for at least 12 weeks, were randomly assigned to receive, in double-blind fashion, coenzyme Q10 (CoQ10; 60 mg, 3 times per day orally) or placebo for 12 weeks. The 45 patients who were receiving hemodialysis at the start of the study were encouraged to decrease the frequency or stop dialysis if there was an increase in urine output and a decrease in serum creatinine of more than 2 mg/dl. In the patients receiving hemodialysis and CoQ10, the mean serum creatinine concentration decreased from 9.5 to 6.7 mg/dl; mean BUN level decreased from 88.2 to 79.8 mg/dl; mean creatinine clearance increased from 40 to 54.9 ml/min; and 24-hour urine output increased from 1,300 to 1,920 ml. Renal function tended to worsen in hemodialysis patients receiving placebo, and the differences in the changes between groups were significant (p < 0.01 to p < 0.001). Significant improvements in each of these parameters relative to the placebo group were also seen in the non-dialysis patients treated with CoQ10. The number of patients requiring dialysis decreased from 21 to 12 in the CoQ10 group, and remained unchanged at 24 in the placebo group (p < 0.02). Eighty-one percent of the patients receiving CoQ10 showed some response to treatment.

I am not familiar with the study that you quote. I have seen some information about the use of Coenzyme Q10 in patients with mitochondrial disease and kidney disease. I currently do not use this treatment in any of my … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, Clinical Trials/Studies, Kidney-Related Health Questions, Medication and Kidney Function

Dear Dr, Greetings! I want to know whether some new medicines are introduced which can delay kidney function deterioration? Usually, Glucose, BP and diet control was prescribed but few claim new medicines are introduced. Is it true? Best regards.

There are new medications that are being explored all the time. The most important ones recently have been the use of ACE-inhibitors and ARB agents to slow progression of chronic kidney disease (CKD). There are other drugs that are undergoing … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, Clinical Trials/Studies, Kidney-Related Health Questions, Medication and Kidney Function

Can anemia be treated with iron shots instead of EPO? I’m concerned about the side effects from the synthetic hormone. Are other treatments available?

Anemia in patients with chronic kidney disease (CKD) should be treated first with iron, if the patient is iron deficient. Once iron deficiency is treated, then drugs such as erythropoietin (EPO) can be used. There are some study drugs that … Continue reading

Posted in Anemia, Ask the Doctor, Chronic Kidney Disease, Clinical Trials/Studies, Kidney-Related Health Questions

I have been on a trial for Roxadustat for 8 years. On March 3, 2019, I was taken off the study after my platelets dropped from 95 to 20. I asked to return to the study after my platelets returned to 89. I am currently in late stage 4 CKD bordering ESRD. GFR 22, HgB 8.5, Creatinine 2.7 I have been having CBC’s every month for the past 3 years. Until the platelets dropped for unknown reasons, Roxadustat maintained my HgB at between 11 and 12. My Nephrologist and Hematologist tried steroids (Prednisone) to try and increase my platelets, which was not effective. We tried a homeopathic remedy of Vitamin K and that brought the readings back up to where they had been before the drop. I am trying to get access to Roxadustat for compassionate use, as my Hgb is now declining more rapidly and my nephrologist agrees that it was effective, but the administrator of the drug trial lab has been reluctant to restart me and says the study will be ending in September anyway. I was diagnosed with stage 3 CKD in 2010 and was informed then that I would likely be on dialysis within 2 years at the rate my kidneys were declining. I got on the Roxadustat trial first for a 27 week study in 2010. That study ended in December 2010 and then I got on an extended study which lasted until March 2019. I have avoided dialysis and having seen the statistics etc. do not plan on either type. I have been told by several Doctors that I am not a good candidate for Procrit or Aranesp due to inflammation diseases I have. My Neprologist has told me that transfusion is an option. I have thought seriously about traveling to China where Roxadustat is approved by the China FDA for use with dialysis patients and is expecting to be approved for non-dialysis very soon. Any suggestions?

There are a number of other anemia drugs that have trials other than Roxadustat. I am familiar with Daprodustat and Vadadustat and there are others. You may be able to find other trails that are available for other drugs. You … Continue reading

Posted in Anemia, Ask the Doctor, Chronic Kidney Disease, Clinical Trials/Studies, Kidney-Related Health Questions, Nephrologist, Transplantation

Hello Dr Spry, I have stage 3 CKD that is stable. However, I wanted to tell you about these websites and open newspaper advertisements for “Stem Cell treatments” for CKD. As I have had CKD for several years and contact with more than one Nephrologist, including you once, I have a small amount of knowledge and have a feeling these people may be the typical “Snake Oil salesmen”. They almost never give the name of the Doctors until one goes deeper into their spiel. The last I knew, stem cell treatments were not approved by any competent authority for CKD treatment. Perhaps I am not up to date, but somehow I get the feeling it is a con job and a lot of gullible sick people will fall for it. What is the position of the National Kidney Foundation?

The National Kidney Foundation has no official position, as far as I am aware, on Stem Cell Treatments or Transplants. We have reported on some funded research into the use of Stem Cells in kidney disease, but there are currently … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, Clinical Trials/Studies, Kidney-Related Health Questions

Stem Cell Therapy for the kidneys. What internet sites provide information on status, test results, etc? Any other suggestions for researching? Thanks.

There is currently no stem cell therapy that is approved by the Food and Drug Administration (FDA) for treatment of any kidney disease. The best web site to look for studies that relate to the use of stem cells for … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, Clinical Trials/Studies, Kidney-Related Health Questions

Hello Doctor, I am CKD stage 4 patient with GFR 25 and will be going to start transplant process soon. I just wanted to know if there are any stem cell clinical trials happening that would help with the transplant or if stem cells have been used on kidney disease patients (humans) as of Dec 2018. Hoping to hear back from you soon. Thanks. Regards.

There are limited trials of the use of a number of different types of stem cells in kidney transplantation. You can review those trials at the web site known as:  www.clinicaltrials.gov I typed in kidney transplantation and stem cells and … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, Clinical Trials/Studies, Kidney-Related Health Questions, Transplantation

Are they developing an artificial kidney? How ready are they and if so when will they be ready?

There are a number of groups that are trying to develop an artificial kidney to be used for patients with kidney failure. There are no currently active studies in humans as yet so they are still several years away from … Continue reading

Posted in Ask the Doctor, Clinical Trials/Studies, Kidney Failure, Kidney-Related Health Questions