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Category Archives: Clinical Trials/Studies
I’ve had a successful kidney transplant for almost 10 years. Is there any way I can get a Covid booster or a 3rd or 4th vaccine? Any trials I can participate in about transplant patients and Covid? I tested negative for anti-bodies. I understand this is not an accurate measure for effectiveness. Is there some other test? I live near UCSF where I got my kidney. Thank you!
A third or booster dose of the COVID-19 vaccine is currently not available in the United States other than by research study by one of the vaccine manufacturers. In the prior studies, patients who are immune suppressed (such as kidney … Continue reading →
Is there a standard of reporting for rare kidney diseases so that doctors, researchers, etc. are aware of the number of cases which may then precipitate additional research, trials, etc? My brother was diagnosed with ABBA and Marginal Zone Lymphoma and it has been really difficult finding out what his best course is since there is no standard of treatment. I would like to know the stats, etc., without medical research jargon that is a little above my knowledge to say the least. There must be underreported cases if proper tested isn’t applied for this diagnosis. Thank you for your time.
The National Organization for Rare Diseases, https://rarediseases.org/for-patients-and-families/information-resources/rare-disease-information/ does a catalog of rare diseases and does fund and sponsor research in this area. You can review this web site and see if this is available. I am not aware of the acronym … Continue reading →
The Wearable Artificial Kidney (WAK) is a blood cleansing device that is still under development. There are no active trials for the WAK at the present time. Please see: https://clinicaltrials.gov/ct2/results?recrs=&cond=Kidney+disease&term=Wearable+artificial+kidney&cntry=&state=&city=&dist=
I do not find a significant difference in any of the available vaccines for patients with chronic kidney disease (CKD). I would suggest that you take any available vaccine. You should discuss this with your primary care physician (PCP) and … Continue reading →
Do you have any information on the artificial kidney that was developed in California. Is it in clinical trials yet? I am a 40 year diabetic that is in end stage renal failure. I am on the kidney and pancreas transplant list. Also had a whippel surgery in 2017 in which 95% of stomach and 50% of pancreas and a heart attack in 2018. I am constantly fighting bacterial overgrowth and malnutrition. If there is any information that you feel would benefit me, please let me know.
The wearable artificial kidney (WAK) is being developed in California and has been tested in two trials. Those two trials have been completed. There are currently no active trials for the WAK. You can monitor these trials by going to … Continue reading →
I just visited my doctor because of the lowering of my kidney function in 3 weeks since I began Carafate for my bile gastritis. I was CKD Stage 2 for ten years and now CKD Stage 3. He said the Carafate wouldn’t have caused such a rise so quickly, and it could be my ppi which I have been on for over 20 years. He wants me to find an alternative medicine for the ppi which I don’t want to do since I have Barrett’s esophagus. I’m still thinking it is the Carafate and not the ppi. What is your opinion, Dr. Spry. I keep my blood pressure and diabetes under control by medicine and diet.
Carafate does not get absorbed into the system circulation and hence is unlikely to affect the kidneys. Proton Pump Inhibitors (PPI’s) have been associated with advancing kidney disease but have not been shown to “cause” kidney disease. The association does … Continue reading →
I donated a kidney 10 years ago. I am 65 years old. My GFR is 58 and a recent 24 hr urine creat clearance came back at 70.92 L (reference range 80.00-110.00) The doctor said all was normal. Do you say these numbers are normal? Should I be concerned?
After donation of a kidney, the expected estimated glomerular filtration rate (eGFR) is between 50 and 70 milliliters per minute per 1.73 meters squared. The normal for the creatinine clearance would be somewhere around 60 to 80 milliliters per minute. … Continue reading →
Hello, I am concerned that the doctor said my dad needs dialysis because of high creatinine level or something. He asked if stem cell surgery is available in Australia or anywhere in the world? Sorry for my basic and amateur language I am just a young boy concerned for his health. Any answer will be appreciated. Thanks.
There are no stem cell therapies that are currently approved by the Food and Drug Administration (FDA) here in the United States. I am not aware of any stem cell therapy that has been shown to be successful in scientific … Continue reading →
Have there been any studies to indicate that stem cell therapy has provided any help in delaying the need for dialysis for people with later stages of kidney disease? Thank You.
There are currently no stem cell treatments that have been approved by the Food and Drug Administration (FDA) for acute or chronic kidney disease (CKD). There is ongoing research into stem cell treatments for patients with CKD. You can go … Continue reading →
Ninety-seven patients (mean age, 48 years) with chronic renal failure (serum creatinine > 5 mg/dl), with a history of declining renal function for at least 12 weeks, were randomly assigned to receive, in double-blind fashion, coenzyme Q10 (CoQ10; 60 mg, 3 times per day orally) or placebo for 12 weeks. The 45 patients who were receiving hemodialysis at the start of the study were encouraged to decrease the frequency or stop dialysis if there was an increase in urine output and a decrease in serum creatinine of more than 2 mg/dl. In the patients receiving hemodialysis and CoQ10, the mean serum creatinine concentration decreased from 9.5 to 6.7 mg/dl; mean BUN level decreased from 88.2 to 79.8 mg/dl; mean creatinine clearance increased from 40 to 54.9 ml/min; and 24-hour urine output increased from 1,300 to 1,920 ml. Renal function tended to worsen in hemodialysis patients receiving placebo, and the differences in the changes between groups were significant (p < 0.01 to p < 0.001). Significant improvements in each of these parameters relative to the placebo group were also seen in the non-dialysis patients treated with CoQ10. The number of patients requiring dialysis decreased from 21 to 12 in the CoQ10 group, and remained unchanged at 24 in the placebo group (p < 0.02). Eighty-one percent of the patients receiving CoQ10 showed some response to treatment.
I am not familiar with the study that you quote. I have seen some information about the use of Coenzyme Q10 in patients with mitochondrial disease and kidney disease. I currently do not use this treatment in any of my … Continue reading →