Category Archives: FSGS

I was just diagnosed with “At least moderately advanced IgA with very focal segmental glomerular necrosis.” This was the results from biopsy. I don’t want to die. I’m only 40 and have 2 children and husband. Please what can I do? My nephrologist hasn’t called me back. I’m very scared and need to know what I can do to help myself live. What is the life expectancy of this disease? My gfr is 33 and creatine 1.7… no meds and no high blood pressure and have been loosing weight to get back to normal weight. Low salt diet and eating healthy and exercising. Please help.

Immunoglobulin A (IgA) nephropathy is a very common kidney disease and does not cause death.  It is a disease that causes blood and protein to be spilled into the urine and can progress to end stage kidney disease whereby dialysis … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, FSGS, Kidney-Related Health Questions, Laboratory Testing

My child is 2 years old. He is suffering from FSGS and steroid resistance. Now his creatinine level is 6 and no treatment is working to control the disease. Kindly guide me in this regard.

The treatment of focal and segmental glomerulosclerosis (FSGS) is very difficult and sometimes is unsuccessful. I am an adult nephrologist and do not have expertise in pediatric nephrologist. I suggest that you consult with a pediatric nephrologist regarding your child.

Posted in Ask the Doctor, FSGS, Kidney-Related Health Questions, Pediatric Issues

I have a question regarding FSGS. Recently a dear person to me told me that she was diagnosed with MCD when she was 6 years old ( biopsy was taken at that time). Few years later she mentioned that another biopsy was taken which showed FSGS. Ever since she was followed up by nephrologists and was on steroids and in 2010 she was on cellcept until she stopped both steroids and cellcept in 2016. She had testing done and her recent test shows only an elevated ACR of 67 which I’m assuming to be subnephrotic range. All her kidney functions and ultrasounds were normal and so for the past 26 years she has had this condition and kidney function seems fine. My question is what are the chances of her going into ESRD and needing dialysis? I know it is difficult to speculate but given a history of what I’m guessing a stable partial remission FSGS what are the likelyhood of needing dialysis down the road? Do all fsgs patients end up on dialysis? Thank you

Focal and segmental glomerulosclerosis (FSGS) has many different courses and many different presentations. There is not just one clinical course for all patients with FSGS. In fact, minimal change disease (MCD) has often been found to evolve into FSGS when … Continue reading

Posted in Ask the Doctor, FSGS, Kidney Biopsy, Kidney-Related Health Questions, Minimal Change Disease

I have FSGS and have tried prednisone, cyclosporine and cellcept but spilling 8g of protein a day. Are there other treatments or medications?

Focal segmental glomerulosclerosis (FSGS) is a scarring disease of the kidney that is relatively uncommon. The treatments that you mention are commonly tried for this disease but FSGS can be very resistant to treatment. ACE-inhibitors or ARB agents are usually … Continue reading

Posted in Ask the Doctor, FSGS, Kidney-Related Health Questions, Medication and Kidney Function, Nephrologist

Hello, I have been recently diagnosed with F.S.G.S. My Doctor is always very positive about everything avoiding straightforward answers (which is common in my side of the world). Protein in the urine has become 1700 mg / l (24 hour test) Creatinine has become 1.4. Both figures are more than few months ago. How can I understand better my FSGS stage? Are these figures indicative and relevant? Is there any particular way to know the progress (I mean deterioration) of my health situation (disease)?

Focal segmental glomerulosclerosis (FSGS) is a scarring disease of the kidney. There are many causes but treatments have not been very effective. The diagnosis is based on findings on a kidney biopsy and there are at least six different classifications … Continue reading

Posted in Ask the Doctor, FSGS, GFR, Kidney Failure, Kidney-Related Health Questions, Proteinuria, Serum Creatinine, Transplantation

Is Rituximab frequently used to treat FSGS (original kidney)?

Focal Segmental Glomerulosclerosis (FSGS) is a relatively uncommon kidney disease. It is commonly divided into primary (of unknown cause) and secondary (of known causes). In cases of primary FSGS, steroids, cyclosporine and other agents are more commonly used. In rare … Continue reading

Posted in Ask the Doctor, FSGS, Kidney-Related Health Questions, Medication and Kidney Disease

I was recently diagnosed with Primary FSGS tip lesion. I was placed on 60mg of Prednisone, along with Lasix, Lisinopril, and potassium. After consulting with my nephrologist and researching on my own, it is my understanding that tip lesion is quite rare and does not have a standard treatment protocol. My question to you is based on current research and information available what type of treatment and length of treatment would you recommend? If I were to seek a second opinion, what doctors in the U.S. have the best understanding about FSGS tip lesion?

Focal segmental glomerulosclerosis (FSGS) is a chronic scarring disease of the kidney and has five different pathological classifications including “tip lesion or variant”.  You are correct that there is no universally recognized treatment for FSGS. The most common treatment is … Continue reading

Posted in Ask the Doctor, FSGS, Kidney-Related Health Questions, Treatments

My 21 year old son was diagnosed with FSGS. His kidneys are functioning at 100% but his protein level was 7000. His nephrologist prescribed cyclosporin. When we researched the drug there was no reference to treating his particular condition and there was a lot of side effects. My questions are: is this an appropriate drug treatment to lower protein levels? Should he ask for tests to be redone before he takes anything since protein levels were unusually high? My 31 year old son also has FSGS. He is in 3rd stage with 45% function but he is not taking this drug. Same doctor. We are a little confused and appreciate any advice.

Focal segmental glomerulosclerosis (FSGS) is a chronic scarring disease of the kidney. In the situation that you describe, I would be concerned about a genetic cause of the FSGS as both of your sons apparently have the disease. I assume … Continue reading

Posted in Ask the Doctor, FSGS, Kidney Biopsy, Kidney-Related Health Questions, Medication and Kidney Function

Hi Doc, I experienced acute renal failure two yrs ago. I had six sessions of dialysis in two weeks and by the fourth session my kidneys were back up functioning normal (0.9creatinine), but my blood pressure was up 150/90 and I started spilling protein ++. My doctor at the time placed me on Losartan and was of the opinion that the protein will stop but it did not. I sought a second opinion from another doctor who placed me on prednisone high dose and reduced it as the weeks progressed but there was no difference as ESR, cholesterol remained high but kidney function remained normal. At this point he ordered a biopsy following which he made a FSGS diagnosis but said I should just keep taking the losartan and made no further treatment plan. I last checked my function last year September and the kidneys still functioned normally but I still spilled protein ++. What can I do to get better although I feel very well.

Unfortunately, kidney disease often has no symptoms at all. Focal segmental glomerulosclerosis (FSGS) is a chronic scarring disease of the kidney and there is no specific treatment. Steroids are often tried, but may not be effective. Uses of drugs such … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Dialysis, FSGS, Kidney-Related Health Questions, Nephrologist

I have stage 4 kidney disease with kidneys functioning at 13%. I have been dealing with this since 2014. It started with hypertension. I had one biopsy done which did not show much other than scarring/fsgs but no other findings. Is there any way for my kidney function to increase on it’s own? Why is it progressing so fast and if I go ahead with transplant, how will I know it won’t continue to decrease being that no one has found out why I have the scarring?

Focal segmental glomerulosclerosis (FSGS) is a scarring kidney disease that causes scarring of the individual glomeruli (filters) of the kidney. It is true that this disease can recur in kidney transplants. The scarring causes progressive loss of glomerular filtration rate … Continue reading

Posted in Ask the Doctor, FSGS, GFR, Kidney-Related Health Questions, Transplantation