Category Archives: FSGS

My mother, age 48, has high bp for more than seven years. Her creatinine level is now 2.6 and had a renal biopsy. (Result shown focal global glomerulosclerosis 3/16 with ischemic changes. Moderate to mild IF/TA 50% and prominent vessel changes consistent with accelerated on benign hypertension). Her creatinine level in Dec-2015 was normal at 0.6 and within three years it reached to 3.0. Please suggest how serious my mother’s kidney health is at present and how to stop the progression of kidney damage?

Focal and global glomerulosclerosis is a scarring disease of the kidney that does not have any known treatment. In general, it is important to keep the blood pressure less than 130/80 and ACE-inhibitors or ARB agents are the most common … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, Dialysis, FSGS, Hypertension/High Blood Pressure, Kidney-Related Health Questions, Transplantation

Hello. Doctor, my brother’s age is 26 years old and he is diagnosed with urine albumin level of 3+ and 24 hour protein of 5250 mg. He has undergone kidney biopsy and the result says that he is having Focal Segmentel Glomerulosclerosis with hypertension related changes. Renal biopsy for direct immunofluorescence shows 7 glomeruli, all of which exhibit patchy segmental and mesangial deposits of IgM (2+) and C3c. The Glomeruli are negative for IgG, IgA, C1q, Kappa and lamba. He’s having creatinine levels as 1.2. Can you please advise if this is a critical health condition or is it curable?

Your brother will need to consult with a nephrologist to determine if the focal segmental glomerulosclerosis (FSGS) is primary or secondary to some other known disease. Hence, your brother must be evaluated by a nephrologist and the decision must be … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Diet/Nutrition, FSGS, Hypertension/High Blood Pressure, Kidney-Related Health Questions, Medication and Kidney Function, Nephrologist

Dear Dr. Spry, Namaste and Good Morning! I am from Nepal and doing treatment of FSGS since 5 years. Please find some basic details: Age: 34 yrs Weight: 66Kg BP: 110/70 Creatinine: range from 0.7 to 1.1 Sugar: No Albumin in Urine: No (As taking Wysolon) Did temporary dialysis as creatinine reached to 7.6 during first time treatment. Medicine: Wysolon (continuous taking since 2.5 yrs), Tachograph (started since 3 months) Problems: Proteinuria. When Wysolon goes to 10mg, it relapses and again Wysolon started with 60mg or 40mg. My main problem is relapse and the side effects of Wysolon. Moon Face, Hair Fall, Fungal Infections, Memory Loss, Weakness, Low Vision, high hemoglobin are some side effects I am facing now a days. Please, suggest solutions to stop proteinuria or minimizing side effects of Wysolon?

You are describing steroid dependent nephrotic syndrome or steroid dependent proteinuria related to focal and segmental glomerulosclerosis (FSGS). This can be a difficult disease to treat. I am unable to recommend medical treatment without performing a complete history and physical … Continue reading

Posted in Ask the Doctor, FSGS, Kidney Biopsy, Kidney-Related Health Questions, Nephrologist

Is FSGS curable?

There is no known cure for focal segmental glomerulosclerosis (FSGS). In most cases, the goal is to slow the progression of the disease.

Posted in Ask the Doctor, FSGS, Kidney-Related Health Questions

My husband aged 26 got through renal biopsy. His report says focal and segmental glomerulosclerosis with moderate arterio and arteriolosclerosis and hyalinosis. His bp is 180/110. His weight is 74 kg. He doesn’t show any symptoms of bp. Protien is lost in urine. Creatinine is 2. 37.

Focal segmental glomerulosclerosis (FSGS) is a chronic scarring disease of the kidney. There are a number of causes of FGSG that should be reviewed with your husband’s nephrologist. His blood pressure should be carefully controlled to less than 130/80 and … Continue reading

Posted in Ask the Doctor, FSGS, Kidney-Related Health Questions, Nephrologist

I was just diagnosed with “At least moderately advanced IgA with very focal segmental glomerular necrosis.” This was the results from biopsy. I don’t want to die. I’m only 40 and have 2 children and husband. Please what can I do? My nephrologist hasn’t called me back. I’m very scared and need to know what I can do to help myself live. What is the life expectancy of this disease? My gfr is 33 and creatine 1.7… no meds and no high blood pressure and have been loosing weight to get back to normal weight. Low salt diet and eating healthy and exercising. Please help.

Immunoglobulin A (IgA) nephropathy is a very common kidney disease and does not cause death.  It is a disease that causes blood and protein to be spilled into the urine and can progress to end stage kidney disease whereby dialysis … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, FSGS, Kidney-Related Health Questions, Laboratory Testing

My child is 2 years old. He is suffering from FSGS and steroid resistance. Now his creatinine level is 6 and no treatment is working to control the disease. Kindly guide me in this regard.

The treatment of focal and segmental glomerulosclerosis (FSGS) is very difficult and sometimes is unsuccessful. I am an adult nephrologist and do not have expertise in pediatric nephrologist. I suggest that you consult with a pediatric nephrologist regarding your child.

Posted in Ask the Doctor, FSGS, Kidney-Related Health Questions, Pediatric Issues

I have a question regarding FSGS. Recently a dear person to me told me that she was diagnosed with MCD when she was 6 years old ( biopsy was taken at that time). Few years later she mentioned that another biopsy was taken which showed FSGS. Ever since she was followed up by nephrologists and was on steroids and in 2010 she was on cellcept until she stopped both steroids and cellcept in 2016. She had testing done and her recent test shows only an elevated ACR of 67 which I’m assuming to be subnephrotic range. All her kidney functions and ultrasounds were normal and so for the past 26 years she has had this condition and kidney function seems fine. My question is what are the chances of her going into ESRD and needing dialysis? I know it is difficult to speculate but given a history of what I’m guessing a stable partial remission FSGS what are the likelyhood of needing dialysis down the road? Do all fsgs patients end up on dialysis? Thank you

Focal and segmental glomerulosclerosis (FSGS) has many different courses and many different presentations. There is not just one clinical course for all patients with FSGS. In fact, minimal change disease (MCD) has often been found to evolve into FSGS when … Continue reading

Posted in Ask the Doctor, FSGS, Kidney Biopsy, Kidney-Related Health Questions, Minimal Change Disease

I have FSGS and have tried prednisone, cyclosporine and cellcept but spilling 8g of protein a day. Are there other treatments or medications?

Focal segmental glomerulosclerosis (FSGS) is a scarring disease of the kidney that is relatively uncommon. The treatments that you mention are commonly tried for this disease but FSGS can be very resistant to treatment. ACE-inhibitors or ARB agents are usually … Continue reading

Posted in Ask the Doctor, FSGS, Kidney-Related Health Questions, Medication and Kidney Function, Nephrologist

Hello, I have been recently diagnosed with F.S.G.S. My Doctor is always very positive about everything avoiding straightforward answers (which is common in my side of the world). Protein in the urine has become 1700 mg / l (24 hour test) Creatinine has become 1.4. Both figures are more than few months ago. How can I understand better my FSGS stage? Are these figures indicative and relevant? Is there any particular way to know the progress (I mean deterioration) of my health situation (disease)?

Focal segmental glomerulosclerosis (FSGS) is a scarring disease of the kidney. There are many causes but treatments have not been very effective. The diagnosis is based on findings on a kidney biopsy and there are at least six different classifications … Continue reading

Posted in Ask the Doctor, FSGS, GFR, Kidney Failure, Kidney-Related Health Questions, Proteinuria, Serum Creatinine, Transplantation