Category Archives: FSGS

Dear Dr. Spry, I am 31 years old. I am a man. I have glomerulonephritis and FSGS for 7 years. Now I take my medicine (Neoral sandimmun 4*25, Prednol 4mg/ day, Olmetec 20mg/day, Drisentin1*1) regularly but last 6 months I had problem with edema around my ankle. Besides edema I have muscle weakness and tiredness. I can’t move as I want to do. I am doing sport but It effects me very much. I can not go on long. I want to ask you how long I should take this kind of treatment? Is there any other treatments for this disease? I am desperate about my future.

Focal segmental glomerulosclerosis (FSGS) is a very difficult disease to treat.  In many cases, the disease is not cured but rather controlled.  If you have concerns about your treatment, this should be discussed with your nephrologist.  I am unable to … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, FSGS, Glomerulonephritis, Kidney-Related Health Questions, Laboratory Testing, Medication and Kidney Function, Nephrologist, Treatments

My husband was told by his Dr. he has FSGS. He had a kidney biopsy. Now the Dr. told him his kidneys are working perfectly. But, something is causing protein to be eliminated in his urine. He is on prednisone. He has high blood pressure, and his leg is still swollen and a pinkish color. Can you help me to understand?

The kidney is not working normally if your husband has excess protein in the urine (proteinuria).  Focal and segmental glomerulosclerosis (FSGS) is a disease that damages the filters of the kidney (glomeruli) and leads to excess protein loss from the … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, FSGS, Kidney-Related Health Questions, Laboratory Testing, Proteinuria, Symptoms and Side Effects, Treatments

I am a male suffering from nephrotic syndrome since I was 22 . Right now, my age is 28 and when I was 6 years old (in 1996) I got my first attack of severe swelling of body and protein loss. After that the attacks was frequent but not much severe then later it was ok. Again severe attack occurred in 2003 and 2012. I keep on using Prednisone from years and recently in August 2016 doctor suggested to stop using steroid as there no attack from many years, but thing is the relapse occurred after my stoppage of medicine within one month i.e. September 2016. During the attack Prednisone dose usage is 60mg /day and then gradually I will reduce the dose to 5mg/day in alternative days. Now I’m steroid dependent and due to this other complication like high cholesterol and hypertension problems being raised. Recent protein/creatine ratio is 600/177 mg/dl. Please suggest me medications, diet and also estimated cost for the treatment if available. I’m unmarried suggest to me whether I can marry or not, so that the girl whom I marry should not face any problems. Thanking you. Hoping for positive feedback.

The disease that you describe is known as Steroid Dependent Nephrotic Syndrome.  It is a very difficult kidney disease to treat.  In some cases, it is necessary to perform a kidney biopsy in order to know exactly what the kidney … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, FSGS, Kidney Biopsy, Kidney-Related Health Questions, Laboratory Testing, Medication and Kidney Disease, Medication and Kidney Function, Nephrologist, Symptoms and Side Effects, Treatments

Hi. I am 18 years old CKD patient, female, diagnosed with “focal crescentic and sclerosing glomerulonephritis”. (I asked you about my kidney biopsy result about a year ago.) My current creatinine level, according to the recent blood / urin examination on July 7th, is 1.02 ml/dl (69.4 ml/dl). And I also have persistent gross hematuria, 3+ with no proteinuria nor albuminuria. I took prednisolone for the past year (to be exact, for 462 days) (I got completely off of prednisolone on May 24th, 2016) and was able to get my creatinine level as low as 0.81 ml/dl (last October) (which my nephrologist said was a miracle) and gross hematuria to 3+ with less red blood cells for the first time since gross hematuria got to 3+. But unfortunately, with more than a year of taking in immuno suppressants, I was struck with influenza this february (which elevated my creatinine level drastically – up to 1.17 ml/dl) and have been getting colds on and off with persistent mild fever (my temperature is always 37.2~37.5 celcius degrees nowadays). Since there’s not much I can do about it medical wise – I have been drinking a cup of ginger tea every morning (raw ginger slices, letting them steep in boiling water) for about 2 weeks now. But what I am worried about is potassium in ginger tea. I know anything steeped in boiling water has a lot of potassium in it and potassium along with sodium, protein, and phosphorus is something CKD patients should be very cautious of. So would drinking ginger tea every day cause problems to my kidneys? Also, any piece of advice on keeping cold at bay and boosting up my immune system back to the way it was?

Ginger tea should not contain much potassium.  I suggest you review the United States Department of Agriculture Nutritional Database and learn about the known concentrations of chemicals in ginger.  You can access this information at: Boosting the immune system … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, FSGS, Kidney Biopsy, Kidney-Related Health Questions, Medication and Kidney Function, Treatments

Our son (age 39) has Focal Segmental Glomerulosclerios since the age of 13. After treatment with many drugs in 1997 he started and still is taking cyclosporine, and also a blood pressure med and one for high cholesterol. His most recent doctor is now telling him he can try stopping his cyclosporine but has blood tests done every month. We worry that his disease will start up again because one time, many years ago he tried and it became active again.

I am unable to provide medical advice without performing a complete history and physical examination.  Focal Segmental Glomerulosclerosis (FSGS) is a very difficult disease to treat.  In some cases, a repeat kidney biopsy may help to guide treatment.  If your … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, FSGS, Hypertension/High Blood Pressure, Kidney-Related Health Questions, Medication and Kidney Function, Nephrologist, Treatments

My late father had fgs and required dialysis for many years. He became aware of his ckd in his mid 40’s and passed away at age 67. His sister also died while on dialysis in her 30’s. And his nephew (from his other sister) has had 2 kidney transplants in his 30’s and 40’s). My question is: my BUN is currently 18 and my creatinine is 1.0. They have been stable around this number for past couple years. I have had a could kidney stones and do have some small cysts on my kidneys via ultrasound. I am a 45 year old white female. Am I at a great risk for developing focal glomerlosclerosis and or kidney disease or would it be more apparent by now if I was genetically destined to develop it? I am also a RN, btw :)

Unfortunately, genetically associated focal and segmental glomerulosclerosis (FSGS) is not a predictable disease.  I have seen it manifest at many different ages in many families.  Some in the young and some in the very elderly.  As you have FSGS in … Continue reading

Posted in Ask the Doctor, FSGS, Kidney-Related Health Questions

I have FSGS and Nephrotic Syndrome as well my kidneys are in Stage 3 of CKD. I am in my mid 20’s and often feel tired and non energetic. I was hoping you can help me find a diet plan for me. I have been thinking of food shopping lists and online recipes but I don’t know where to begin. Also I have GERD so, food is very confusing for me these days. For I have two different conditions as well as high blood pressure and Cholesterol. Please help me for a healthy meal is a healthy life for me and a better happier me.

I am a strong proponent of the DASH diet for patients with chronic kidney disease (CKD) Stage 3.  You should follow a low salt diet and limit sodium in the diet to less than 2300 milligrams per day.  You can … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, Diet/Nutrition, FSGS, Kidney-Related Health Questions

My son is 17; he was diagnosed with FSGS secondary. He has a twin brother. Is stem cell transplant from twin a good treatment and where is this done if so?

Stem cell transplantation is not a recognized treatment for focal segmental glomerulosclerosis (FSGS).  I am not aware of any trials to study this treatment.

Posted in Ask the Doctor, Chronic Kidney Disease, Clinical Trials/Studies, FSGS

What causes fsgs in kidneys? I was fortunate to receive a kidney transplant but have been told I now have fsgs. How can this be?

We do not know the cause of focal and segmental glomerulosclerosis (FSGS).  There are many associations with FSGS but we do not know of the exact pathophysiological mechanism for injury to the kidney.  Since you have recurrence of FSGS in your transplanted … Continue reading

Posted in Chronic Kidney Disease, FSGS, Kidney-Related Health Questions, Transplantation

I was diagnosed with “focal crescentic and sclerosing glomerulonephritis” and CKD, stage 3 after getting renal biopsy and have been on corticosteroids (prednisone) since February 16th. I took 30mg of pd every single day for the last 6 months and recently started tapering on steroids due to their side effects. (Currently taking 4 tabs each day.) Also, I’m 17 years old, female. There aren’t enough information on the Internet regarding my renal disease. (Even no academic materials.) The symptoms that I have are weird. Peculiar? Not fitting to what my kidneys are going through? (That’s what my doctor said. Sorry for the poor English.) My creatinine level is at 0.93 (this was tested two weeks ago so it’s accurate.) although gross hematuria has been persistent at 3+ for over a year. (When I was taking 6 tabs of steroids, it was reduced to 2+ but now it’s back to 3+. And yes, hematuria is not by urologic cause.). I do not have proteinuria or albuminuria. BUN is low (normal). All the indicators showing ‘renal disease’ or ‘glomerular dysfunction’ are normal – except for gross hematuria and creatinine (and cystatin C but lab doesn’t test it every time I get my blood taken.) The doctor didn’t consider of me getting renal biopsy at first – I have been going to the nephrology since 2013 and all of the doctors from different hospitals who I met said it would be IgA nephropathy and there would be nothing to worry about. But after taking DTPA renogram this January and finding out that blood flow and function in the bilateral kidneys were decreased (24.09 ml/min on the right, 33.98 ml/min on the left), renal biopsy was done and voila. Focal crescental and sclerotic glomerulonephritis. So will you please explain what exactly is happening to my kidneys? Please? It would be of great help. Here’s my renal biopsy results. I hope I provided enough information needed for your analysis. Thanks. The sections demonstrate one core of renal cortex and medulla, containing 31 glomeruli per section. Three glomeruli show global sclerosis. One glomerulus shows synechia at tip area. Nine glomeruli show ischemic collapse and associated with synechia in one. Two glomeruli show cellulr crescents and one glomerulus shows fibrocellulr crescent formation. Non-sclerotic glomeruli show minimal mesangial expansion without hypercellularity. The glomerular capillary loops are patent without collapse. The glomerular basement membrane is not thickened. The tubules show moderate atrophy and casts. The interstitium is widened by mild fibrosis and moderate mononuclear infiltrate. The blood vessels are not remarkable. The sections were reacted with antibodies specific for heavy chains of IgG, IgA, and IgM, and against C3, C4, C1q, fibrinogen, kappa and lambda. There are no glomeruli present.

From the description of the biopsy, I would likely call this a focal and segmental glomerulosclerosis (FSGS) with crescents.  The cause of the disease is unknown.  In most cases, we try to control the disease with steroids (as in your … Continue reading

Posted in Chronic Kidney Disease, FSGS, Kidney-Related Health Questions