Category Archives: GFR

My wife is 51 years old. Her creatinine level was always below 0.97. On 18 April, her creatinine level rose at 1.41 and gfr was at 51. On 25 May her creatinine level was 137.6 umol/L and gfr went down to 37. In the 1st investigation period she was having fever and in the 2nd investigation period she had coughing. Now her creatinine level is 1.55 even though she is on 30gm protein level diet plan. What is the cause of quick drop of her gfr?

I am unable to make a specific diagnosis based on the information that you present.  This appears to be something that is causing acute kidney injury.  I recommend consultation with your physician and further testing as to why she is … Continue reading

Posted in Acute Kidney Injury, Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, Diet/Nutrition, GFR, Kidney Failure, Kidney-Related Health Questions, Symptoms and Side Effects

I have a family history of CAD, hypertension and kidney failure. I am 40 year old, normal weight, non-hypertensive, non-smoking, non-drinking female taking only levothyroxine for my thyroid. All of my labwork is within normal range except my GFR, which is 59. What does this mean for my kidneys?

Normal kidney function is to have an estimated glomerular filtration rate (eGFR) greater than 60 milliliters per minute per 1.73 meters squared. I am unable to make a specific diagnosis based on the information that you present.  This may be … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, GFR, Kidney-Related Health Questions, Laboratory Testing, Symptoms and Side Effects

I am a healthy 24 year old white male taking 1 gram of Valtrex/day for the last 18 months. I have no symptoms but on a routine blood test my kidney functions were Cr of 1.87, BUN of 27, BUN/Cr ratio of 14 and a eGFR of 49. Urinalysis shows no protein. I discontinued Valtrex 5 days ago and will have a second blood test plus a 24 hr urine collection. My question is: is increasing intake of fluids and possibly consuming cherry juice as it’s done for gout help my kidneys recover from crystal deposition? I have no medical problems, my BP is 110/70.

The testing that you describe, if it remains abnormal for more than 3 months, does suggest that you have chronic kidney disease (CKD).  I am unable to make a specific diagnosis based on the information that you present.  If you … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, GFR, Hypertension/High Blood Pressure, Kidney-Related Health Questions, Laboratory Testing, Symptoms and Side Effects, Treatments

I underwent a nephrectomy on April 3 whereby my left kidney and large tumor was removed. I have had a number of blood tests since then and have noticed that my BUN and creatinine are not within normal ranges BUN (35) creatinine (1.70) and my egfr is currently (June 13,) at 40. Should I be concerned at this point? I assume that without one kidney it would be low.

After undergoing removal of a kidney, your kidney function tests will be abnormal and the estimated glomerular filtration rate (eGFR) will be low.  After removal of one kidney, I would expect the eGFR to be in the range of 50 … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, GFR, Kidney-Related Health Questions, Laboratory Testing, Nephrectomy / One kidney, Symptoms and Side Effects, Treatments

Hi Dr. Spry — 39/yo amateur bodybuilder here. I learned a couple years ago that I have kidney dysplasia, one side completely polycystic kidney and the other mildly hypertrophied. I am used to my creatinine running high (over 1.3) and GFR just shy of 60. However some recent labs have disturbed me! Serum Creatinine 2.0 — note that I weigh ~100kg/225lbs largely muscle, this has crept up over time correlated with my weight gain (1.3, 1.5, 1.7, 1.8…) 24 hr urine contained 2.3g protein! — note that I didn’t know not to train, and trained legs (intensely) the day of sample collection eGFR 35-40 — could this be related to creatinine? BUN 44 — Note that I have been on very high protein diet, upwards of 4g/kg (400-450g total) I have been on Losartan for hypertension for about a year and a half. My BP is usually well controlled. Due to some other chronic illness (HIV, well controlled CD4 healthy normal range) I track my lab values in a spreadsheet. I can see a correlation between my weight/muscle gains from 200-220lbs and the increased serum creatinine and reduced eGFR. When I learned that I had the kidney dysplasia I had a proper radioactive measurement, and all I have in my notes is that GFR was fine and healthy for one kidney. Questions: 1. Is it possible/believable that this is all caused by my atypical muscle mass and intense training? (High creatinine, thus low GFR, exercise induced proteinuria) 2. With the kidney dysplasia, do I technically have CKD with basically 50% of a normal person’s kidney function? I am freaked out thinking that I’ve suddenly in the last 9-12 months had some sudden kidney injury!

By definition, you have chronic kidney disease (CKD) because the dysplastic polycystic kidney has been present for at least three months.  Hence, you do have reduced kidney function.  The body building that you are doing will increase the serum creatinine … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, GFR, Kidney-Related Health Questions, Laboratory Testing, Nephrologist, Symptoms and Side Effects, Treatments

My labs came back showing creatinine 0.8, no protein in my urine yet it showed my egfr as 73. I am a 54 Caucasian female and was wondering why my GFR shows 84 when I use an online gfr calculator. Why does my labs (blood work) show it much lower?

The online calculator calculates the estimated glomerular filtration rate (eGFR) in units that include your body size and is adjusted to a body surface area (BSA) of 1.73 meters squared.  The number can be changed by either including your body … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, GFR, Kidney-Related Health Questions, Laboratory Testing

I have a kidney eGFR was 38. Then prescribed Metformin 500 mg 1in morning. Now my eGFR is 27. I think it’s because of metformin? Is it possible?

Metformin is a drug used to treat diabetes and should not be used with an estimated glomerular filtration rate (eGFR) less than 30 milliliters per minute per 1.73 meters squared.  Metformin may cause liver injury with a low eGFR but … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, Diabetes, GFR, Kidney-Related Health Questions, Laboratory Testing, Medication and Kidney Disease, Medication and Kidney Function, Symptoms and Side Effects

Hi, I’m 55 years old. I had a kidney infection back in December and another one two weeks ago both showing blood in urine and decreased kidney function. Last week, blood tests yielded Creatinine 1.15 and GFR Non African American 54. My family doctor said that we should monitor for now and that I am in Stage 1 of renal failure. On charts that I have looked at, the numbers that I have seem representative of Stage 3 renal failure and maybe a change of diet is needed or perhaps a visit to a kidney doctor. Are the numbers truly representative of Stage 1 or Stage 3? Should I see a kidney doctor?

The Stages of chronic kidney disease (CKD) require that a test be abnormal for at least three months before we designate them to be CKD.  We do not refer to them as stages of kidney failure.  Kidney failure implies kidney … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, GFR, Kidney-Related Health Questions, Laboratory Testing, Symptoms and Side Effects, Treatments

My husband gets blood work done every 6 months for the last 20 years due to a pituitary adenoma. His Comprehensive Metabolic Panel has always been normal until 2 years ago. His creatinine went from a 1.21 in January 2015 to a 1.46 in August 2015. He had a 24 urine test done in November 2015 and it showed normal kidney function. The doctor said kidney function was 110%. Since then these have been his creatinine results – (range 0.60 – 1.35mg-dl) 11/2015 – 1.33 1/2016 – 1.22 10/2016 – 1.39 12/2016 – 1.29 5/2017 – 1.37 All other results with the panel are normal. My question is – are these fluctuations anything to be concerned about? His diet hasn’t changed, all he drinks is water so he can’t be dehydrated (same amount all the time), exercise hasn’t changed either.

The laboratory values that you report for the serum creatinine on your husband are not different from each other.  These values are within normal laboratory variation for the serum creatinine test.  There is a natural loss of kidney function with … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, Diet/Nutrition, GFR, Kidney-Related Health Questions, Laboratory Testing, Serum Creatinine, Treatments

My GFR keeps changing from GFR 27 to 32 then from GFR 29 to 34. I was getting ready to gain access point but now my GFR puts me back in stage 3. Please tell me why my GFR keeps changing and wilL I stay in Stage 3?

The estimated glomerular filtration rate (eGFR) is just an estimate and is not an exact number.  The laboratory testing does have some variability and will tend to vary from day to day.  The numbers that you quote are very similar … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, GFR, Kidney-Related Health Questions, Laboratory Testing, Symptoms and Side Effects, Treatments