Category Archives: GFR

Doc, Three years ago I had kidney failure. My creatinine level was 10. I had no pain or illness, just out of my mind. Kidney Doc determined use of NSAIDs, Aleve, metformin, lisinopril made a perfect storm. Since, my creatinine levels have remained 1.0-1.04. No higher. I’m a 58 yo male, 5’9” 150 pounds. I’ve haven’t taken anything NSAIDs, metformin, and only 5mg lisinopril daily. I’m Type 2 diabetic. I have to take morphine sulfate 15mg x 3 and 10mg Oxycodone x 2 daily for chronic pain due to combat injuries. My kidney doc stated he moved me to stage 2 two years ago only because he couldn’t just move me from 3 to 1 automatically. Can I be considered cured? I long to drink a cold beer on a hot day.

After an episode of acute kidney injury, there is often residual kidney damage that has been done. I cannot determine if your kidney function is back to normal based on the information that you present. I suggest that you continue … Continue reading

Posted in Acute Kidney Injury, Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, Diabetes, GFR, Kidney-Related Health Questions, Serum Creatinine

I am a 45 yr old female, non-smoker, with Postural Orthostatic Tachycardia Syndrome (POTS) and ADHD. Recent blood tests from my neurologist indicated rising creatinine (0.8 to 1.05 over past 14 months) and decreasing eGFR (91 to 64 same time period). Looks suspicious to me, but I take florinef (plus 8-10 g salt and 4 L water) and clonidine for POTS (and buproprion and strattera for ADHD). Do you know if the POTS treatment could artificially change the creatinine and eGFR results in the absence of actual kidney disease?

I am unable to make a specific diagnosis based on the information that you present. I am not aware of any information about the use of the medications that you mention having any direct effect on kidney function tests. The … Continue reading

Posted in Ask the Doctor, GFR, Kidney-Related Health Questions

Hi Doctor, I am a CKD patient and my creatinine levels and GFR keeps fluctuating. My last reports were Creatininine 1.4 & GFR 49 and report after that was 1.6 and GFR as 40. I don’t know what went wrong. Please help me. I am 30 years old married woman living in SFO.

The variation in your serum creatinine and your estimated glomerular filtration rate (eGFR) could just be normal laboratory variation. The laboratory measurement of creatinine can vary by 0.2 milligrams per deciliter (mg/dl) from day to day. I am not able … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, GFR, Kidney-Related Health Questions, Serum Creatinine

I a 48 year old caucasian male, diagnosed with Stage 3 CKD in 2017, biopsy confirmed IgAN in January of this year, was started on Prednisone and SoluMedrol for 6 months. With two more weeks of Prednisone treatment. For the first time in 18 months I have no Hemoglobin or RBC in my urine. However, my creatinine level has remained around 1.6 and my GFR is 47, it was 46 at the beginning of treatment in January. Is the resolving of hematuria (given no appreciable improvement in GFR) reason to celebrate? Or with no improvement in GFR has Prednisone not worked for me? I have not had an issue spilling protein, until I convinced my nephrologist to allow me to suspend Lisinopril for 2 months. Once I restarted the 10mg of Lisinopril my protein spillage resolved. I have read that hematuria and proteinuria are bad prognostic predictors for progression of IgAN towards ESRD. I remain hopeful with these resolved, however am confused why my eGFR or creatinine are not also showing improvement.

In the case of glomerulonephritis and in the specific case of Immunoglobulin A nephropathy (IgA nephropathy), once glomeruli have been destroyed by disease, it may not be possible to repair old ones and it is NOT possible to build new … Continue reading

Posted in Ask the Doctor, GFR, Glomerulonephritis, Hematuria, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions, Proteinuria

Typically healthy female 31, ht 63 inches, wt 137. GFR 69-75. Is this normal? How much does a GFR vary day to day?

This is likely normal laboratory variation in the testing. A normal estimated glomerular filtration rate (eGFR) is greater than 60 milliliters per minute per 1.73 meters squared. Hence, your eGFR is normal. Laboratory measurements of eGFR may vary by 10 … Continue reading

Posted in Ask the Doctor, GFR, Kidney-Related Health Questions

My sister (34 yrs) is recently diagnosed with IGA Nephropathy (M1 E1 S0 T1 C1) with focal crescents based on biopsy. She was put on Solumedrol 500mg (3 doses completed by 22nd March) then started on following medications: a. T Defstead 30mg 1-0-0 b. T Mystead 500mg 1-0-1 c. Zyloric 100mg 0-0-1 d. Shelcal 500mg 1-0-1 e. Maxepa 1-1-1 f. Amlong 5mg 1-0-1 g. Rantac 1-0-1. This controlled her Cr to 3.1 for 2 months and then again started increasing. It has increased to 4.1 now and doctor is suggesting for dialysis/transplant. The doubt I have is, she urinates a lot however one of the symptom of IGA nephropathy is less urination. Is she in good hands? Please suggest.

Urine volume is not a good indicator of kidney function. Kidney disease, including IgA nephropathy, causes a decrease in the estimated glomerular filtration rate (eGFR), but it does not usually cause a change in urine volume. I suggest that your … Continue reading

Posted in Ask the Doctor, GFR, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions

I realize I’m at stage 3. My doctor wants me to avoid ibuprofen as much as possible, but it is helpful a couple times a month for my osteoarthritis of the knee. I’m almost 70, and had prior hi BP which is controlled now and I have no diabetes. Don’t smoke, drink, or do drugs. Weigh 188. Non African American. My EGFR values since 2015 to present. 45 48 51 48 46 45 50 49 How bad is it to take ibuprofen 2-3 times a month?

Ibuprofen removes the ability of the kidney to protect itself in times of stress and it directly decreases the estimated glomerular filtration rate (eGFR) on the days that you take the drug. Long term use can lead to permanent kidney … Continue reading

Posted in Ask the Doctor, GFR, Kidney-Related Health Questions

My nephrologist doctor told me I have stage 3 kidney disease. I checked all my blood work levels from 2013 to present paying close attention to the test that reveals kidney disease. I completed all my figures in to averages and my results are as follows: UREA NITROGER 25.46 CREATININE 1.309 GFR 56.77. My age is 65 and weight is 190 lbs. Is this actually stage 3 kidney disease and should I be concerned from these numbers?

According to the National Kidney Foundation (NKF) staging criteria, if you have an estimated glomerular filtration rate (eGFR) of less than 60 milliliters per minute per 1.73 meters squared and this has been present for more than 3 months, then … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, GFR, Kidney-Related Health Questions

Hi. I am 56 and was diagnosed with type 1 diabetes at age 7. Latest creatinine was 2.4 and eGFR was 22. What does this mean in reference to my CKD which was at stage 3b last year? I am very anemic and just had blood transfusion a week before these labs were drawn?

Stage 3b chronic kidney disease (CKD) means that your estimated glomerular filtration rate (eGFR) was between 30 and 45 milliliters per minute per 1.73 meters squared and was so for at least three months. If your eGFR is now between … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, GFR, Kidney-Related Health Questions, Nephrologist

Hi. I have a question. I am a 27 year old male with an athletic build and I weigh 175 lbs. The past three years my GFR has been 75, 90 and 85 and I just feel for how young I am that this is pretty low? Past urine exams yielded no abnormal results. Am I good or should I see a nephrologist?

The normal estimated glomerular filtration rate (eGFR) is greater than 60 milliliters per minute per 1.73 meters squared. Hence, the values that you quote are within the normal range. Since your urine testing is also normal, I do not identify … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, GFR, Kidney-Related Health Questions