Category Archives: Glomerulonephritis

I would like to know about neufropaty in c3, what is the best form of treatment and because it is a rare disease is there cure or at least control?

C3 glomerulonephritis is a relatively rare and recently recognized form of glomerulonephritis. It is thought to be caused by abnormalities in the regulation of complement proteins in your immune system. This can be a very complex disease to care for … Continue reading

Posted in Ask the Doctor, Glomerulonephritis, Kidney-Related Health Questions, Nephrologist

My GFR has dropped from 94 to 33 in 2 years. I’m going to a specialist. I’m really scared. How can a seemingly healthy male, 59, go down this far so quickly?

I am unable to provide a specific diagnosis based on the information that you present. There are many types of acute kidney injury and glomerulonephritis that could be considered. Your consultation with a nephrologist is appropriate. Further testing will be … Continue reading

Posted in Acute Kidney Injury, Ask the Doctor, Glomerulonephritis, Kidney-Related Health Questions, Nephrologist

My disease is nephritic syndrome. What shall I do doctor?

The nephritic syndrome is commonly called a glomerulonephritis. This is an inflammation of the kidney. In most cases, a kidney biopsy is necessary in order to determine a more specific diagnosis. The more specific diagnosis will lead to more specific … Continue reading

Posted in Ask the Doctor, Glomerulonephritis, Kidney Biopsy, Kidney-Related Health Questions

For membranous nephropathy, does rituxan or prednisolone/cytoxan have a better cure rate, less chance of reoccurance and side effects? Is there anything to consider when choosing treatment? Thanks.

There are no studies comparing Rituxan (Rituximab) with Cyclophosphamide (Cytoxan)/Prednisone combination. The recent discovery that Anti-Phospholipase A2 Receptor (Anti-PLA2R) antibody is often associated with primary membranous glomerulonephritis has allowed us to understand some of the potential causes for this kidney … Continue reading

Posted in Ask the Doctor, Glomerulonephritis, Kidney-Related Health Questions

Sir, I am suffering from nephrotic syndrome in C3 glomerulopathy/DDD. Doctor says that it found in Two Million to one. I can not change my kidney because antibody attack again to new kidney. So please, Doctor, guide what I can do?

Your physician is correct that C3 glomerulopathy/Dense Deposit Disease (DDD) is a very uncommon kidney disease. It is also very difficult to treat. There have been some reports of using Eculizumab (Soliris) or Rituximab (Rituxan) in the treatment of this … Continue reading

Posted in Ask the Doctor, Glomerulonephritis, Kidney-Related Health Questions, Transplantation

Dear Doc, I’m 47 years old, I’m Italian and I have a kidney disease from May 2017. A glomerulonephritis membranous idiopathic secondary (after a biopsy of my kidney). I did all blood test (including FBC, inflammatory markers, and special tests (including ASLO, ANCA, Anti-GBM, Complement levels, Anti-nuclear antibodies). All negative, no diabetes, no high pressure, no lupus etc etc. I did a Ponticelli therapy but unfortunately I’m cortisone-resistant. Now, my doctor would like to investigate more making me a colonoscopy and gastroscopy. So, my question is: has a case happened like mine? Thank you

Many of the cases of Membranous Glomerulonephritis have been shown to be related and potentially caused by antibodies to Anti-Phospholipase A2 receptors (Anti-PLA2R). This could be a potential in your situation. It might be worth checking for Anti-PLA2R in your … Continue reading

Posted in Ask the Doctor, Glomerulonephritis, Kidney-Related Health Questions

Dear Dr.Spry, I am asking this question for my 12 yr old kid. Three months back his foot and eyes swelled, 3+ albumin in urine, 275 mg cholesterol in blood. We consulted a doctor. He told us this happened because the antibodies, produced in his body against some pathogenic bacteria, had reacted with kidneys and caused kidney damage. Doctor suggested antibiotic and steroid treatment, after 1 week swelling disappeared albumin and cholesterol come to normal. Having said that, I would like to know (1) the antibodies produced against a pathogenic bacterium attack the kidney? (2) If so which are those pathogenic bacteria? Thanking you.

From your description, it sounds like the physician has made the diagnosis of Post Streptococcal Glomerulonephritis. This kidney disease occurs about 1 to 6 weeks after exposure to Group A Beta-hemolytic Streptococci. After the infection clears, the body makes antibodies … Continue reading

Posted in Ask the Doctor, Glomerulonephritis, Kidney-Related Health Questions

My daughter is 22 yrs old and has had either a +1 or +2 protein and +1 to +3 blood in all of her urine tests since 2015. Had a cystoscopy done that showed nothing. Now she has a positive ANA titer of 1:1620, sed rate of 24, and c reactive protein of 1.22. White blood count of 11.2 Strong urge to urinate all the time but no infection. Not real obvious swelling but she complains of sore joints and she gets puffy under her eyes. Her total protein/creatinine ratio is 341.1 but her eGFR says >60. Rheumatologist ran 13 tubes of blood and she’s tested neg for all major autoimmune diseases. But there is obviously some type of inflammation issue going on somewhere in her body. Could all of her positive protein and blood urine tests be causing the positive ANA test? And should we be concerned that there is a kidney issue going on?

I am unable to provide a specific diagnosis based on the information that you present. In some cases a kidney biopsy is necessary to make a specific diagnosis of inflammation of the kidney. This could be some form of glomerulonephritis … Continue reading

Posted in Ask the Doctor, Glomerulonephritis, Kidney Biopsy, Kidney-Related Health Questions, Nephrologist

I a 48 year old caucasian male, diagnosed with Stage 3 CKD in 2017, biopsy confirmed IgAN in January of this year, was started on Prednisone and SoluMedrol for 6 months. With two more weeks of Prednisone treatment. For the first time in 18 months I have no Hemoglobin or RBC in my urine. However, my creatinine level has remained around 1.6 and my GFR is 47, it was 46 at the beginning of treatment in January. Is the resolving of hematuria (given no appreciable improvement in GFR) reason to celebrate? Or with no improvement in GFR has Prednisone not worked for me? I have not had an issue spilling protein, until I convinced my nephrologist to allow me to suspend Lisinopril for 2 months. Once I restarted the 10mg of Lisinopril my protein spillage resolved. I have read that hematuria and proteinuria are bad prognostic predictors for progression of IgAN towards ESRD. I remain hopeful with these resolved, however am confused why my eGFR or creatinine are not also showing improvement.

In the case of glomerulonephritis and in the specific case of Immunoglobulin A nephropathy (IgA nephropathy), once glomeruli have been destroyed by disease, it may not be possible to repair old ones and it is NOT possible to build new … Continue reading

Posted in Ask the Doctor, GFR, Glomerulonephritis, Hematuria, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions, Proteinuria

I have stage 3 kidney disease. I have several tests and still no clue as to why I have at least 2000 mg of protein spewing into my urine. What other reasons are there? I’m 40 and have children. Back in 2016, it was 42, didn’t know and now it is 33. I don’t want to die. I have a biopsy scheduled in a few weeks. No family problems, no high blood pressure or diabetes. Been loosing weight. Drinking lots of water. I am working with specialist but need more answers, Please.

The kidney biopsy should supply the answers you are seeking. There are forms of kidney disease, including glomerulonephritis, that can only be determined with a kidney biopsy. There are no specific blood tests for glomerulonephritis and a biopsy must be … Continue reading

Posted in Ask the Doctor, Glomerulonephritis, Kidney Biopsy, Kidney-Related Health Questions