Category Archives: Glomerulonephritis

I a 48 year old caucasian male, diagnosed with Stage 3 CKD in 2017, biopsy confirmed IgAN in January of this year, was started on Prednisone and SoluMedrol for 6 months. With two more weeks of Prednisone treatment. For the first time in 18 months I have no Hemoglobin or RBC in my urine. However, my creatinine level has remained around 1.6 and my GFR is 47, it was 46 at the beginning of treatment in January. Is the resolving of hematuria (given no appreciable improvement in GFR) reason to celebrate? Or with no improvement in GFR has Prednisone not worked for me? I have not had an issue spilling protein, until I convinced my nephrologist to allow me to suspend Lisinopril for 2 months. Once I restarted the 10mg of Lisinopril my protein spillage resolved. I have read that hematuria and proteinuria are bad prognostic predictors for progression of IgAN towards ESRD. I remain hopeful with these resolved, however am confused why my eGFR or creatinine are not also showing improvement.

In the case of glomerulonephritis and in the specific case of Immunoglobulin A nephropathy (IgA nephropathy), once glomeruli have been destroyed by disease, it may not be possible to repair old ones and it is NOT possible to build new … Continue reading

Posted in Ask the Doctor, GFR, Glomerulonephritis, Hematuria, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions, Proteinuria

I have stage 3 kidney disease. I have several tests and still no clue as to why I have at least 2000 mg of protein spewing into my urine. What other reasons are there? I’m 40 and have children. Back in 2016, it was 42, didn’t know and now it is 33. I don’t want to die. I have a biopsy scheduled in a few weeks. No family problems, no high blood pressure or diabetes. Been loosing weight. Drinking lots of water. I am working with specialist but need more answers, Please.

The kidney biopsy should supply the answers you are seeking. There are forms of kidney disease, including glomerulonephritis, that can only be determined with a kidney biopsy. There are no specific blood tests for glomerulonephritis and a biopsy must be … Continue reading

Posted in Ask the Doctor, Glomerulonephritis, Kidney Biopsy, Kidney-Related Health Questions

I was seen in the ER for back pain. I was evaluated for a kidney stone via CT which was negative. Simple cysts were noted on the CT report. Musculosceletol strain was the final dx and I was sent home with Mobic for 10 days. An incidental finding of microscopic hematuria (5.3/HPF) and trace protein led to a renal and bladder sonogram, more labwork, and a follow-up with a urologist who performed a bladder cystoscopy, sent cells for review, and a digital rectal exam which were all negative. My labs were fairly normal, BUN 13, Creatinine 0.88, GFR >60, PSA 0.14. I did have a slightly elevated WBC of 11.3, and very high triglycerides of 592. Now my family MD wants me to see a Nephrologist for further evaluation of the hematuria. After doing some online research, I feel that we should just recheck the urine monthly and wait a bit. What are your thoughts on this approach. What further testing would the Nephrologist suggest that hasn’t been done?

If there are red blood cells in the urine, the nephrologist can examine the urine to discover if the red blood cells have characteristics that suggest they are coming from the bladder or coming from the kidney.  Red blood cells … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, Glomerulonephritis, Kidney-Related Health Questions

Doctor, we have a 10 year old who has had multiple strep infections, was thought to have had glomerulonephritis at that time. Then as a precaution had tonsils out, now at age 21 with no other infections present has the same kidney symptoms without infection. Can this be due to exposure to chemicals at his work?

I am not able to make a specific diagnosis based on the information that you present. It is true that streptococcal infections can be associated with inflammation within the kidneys (glomerulonephritis). In some cases, this may require a kidney biopsy … Continue reading

Posted in Ask the Doctor, Glomerulonephritis, Kidney Biopsy, Kidney-Related Health Questions

Good day… I have a question about my daughter she is 7 years old. She was confined in the hospital last September because she was diagnosed with acute glomerulonephritis. What does acute glomerulonephritis mean?

Glomerulonephritis is inflammation of the filters of the kidney known as glomeruli. The inflammation may destroy the little filters and this will cause a reduction in kidney function. It is common for glomerulonephritis to cause blood and protein to spill … Continue reading

Posted in Ask the Doctor, Glomerulonephritis, Kidney-Related Health Questions, Pediatric Issues

Thank you so much, Dr. Spry. I have Lupus, Sjogren’s, and Hashimoto’s. I got bloodwork back the other day and my eGFR was down from 75 May 2, to 66 Sept. 1. My (random) urine was checked and Albumin was 40.8% & Total Protein was 23.3. UAlbumin 40.8% (9.5 mg/dl) UAlpha1 59.2% (13.8mg/dl). Urine Creatinine 189.5 mg/dL. My SERUM BUN/Creatinine Ratio was Low @ 8. SERUM Creatinine is 0.96 (rising). The nurse indicated that there was nothing remarkable about these values. My father was on dialysis for years and passed at 63. Glomerulonepritis. I am 57 now. I think these values warrant further investigation, as kidney disease has affected several other paternal relatives as well. But I don’t know how to go about doing anything about it. I am concerned about Lupus Nephritis, also. I have Anemia of Chronic Disease, and Polyclonal Hypergammaglobulinemia dx through a bone marrow aspirate nearly 20 years ago. But no one ever knew what to do with that information. I’m very worried about my kidneys. Can you help me understand if my concerns are warranted? Thanks again, in advance.

When interpreting the estimated glomerular filtration rate (eGFR), we use normal as being anything greater than 60 milliliters per minute per 1.73 meters squared. Hence, the laboratory cannot reliably tell the difference between 75 and 66. These numbers within the … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, Dialysis, GFR, Glomerulonephritis, Kidney-Related Health Questions, Laboratory Testing, Lupus

What causes too much protein in your urine?

There are many causes of protein in the urine.  A small amount of protein is normally in the urine.  If the protein loss into the urine becomes excessive, then this is seen in glomerulonephritis, heavy physical exercise, fever, and can … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, Glomerulonephritis, Kidney-Related Health Questions, Laboratory Testing, Risk factors

I am 30 years old and I have stage 3 entering stage 4 kidney disease. It was caused by glomerulonephritis, to be exact. So when my nephrologist and specialist did the biopsy, they started me on first treatment of steroids at 120 mg until I eventually got to 5 mg, along with mycophenolate. After I finished the course of medications, the doctors saw my body didn’t react to any of the treatments. So my question, is this common and is it heard of?

Not everyone responds to conventional treatments for glomerulonephritis.  The type of glomerulonephritis is of importance.  Some types respond very well and other types do not.  I suggest that you discuss your concerns with your nephrologist and learn the exact diagnosis … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, GFR, Glomerulonephritis, Kidney-Related Health Questions, Nephrologist, Treatments

Hi Dr. I was recently diagnosed with stage 3 kidney disease. My mother had it as well 20 or so years ago. She did in time end up on dialysis. With this being genetic, will I also end up on dialysis? Is that the normal path of the inherited disease?

There are many different kidney diseases that can be inherited including polycystic kidney disease, Alport’s syndrome, diabetes, and other forms of glomerulonephritis.  I am unable to make a specific diagnosis based on the information that you present.  I suggest that … Continue reading

Posted in Alport Syndrome, Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, Diabetes, Glomerulonephritis, Kidney-Related Health Questions, Laboratory Testing, Polycystic Kidney Disease, Symptoms and Side Effects, Treatments

Hello I actually have a couple of questions. Infected with hepatitis C from 13 months of age until SVR due to anti-viral therapy at 28 years. Asymptomatic the entire with virtually no detectable effects of the virus aside from active RNA. I have been told that the immune complexes formed by the body fighting the virus are at least partially removed by the kidneys. So my first question is: How accurate is that? My second question is: After 25+ years of this happening, what is the likelihood that there would be any amount glomerulonephritis present?

Hepatitis C can be associated with glomerulonephritis and chronic kidney disease (CKD).  It is true that immune complexes can be formed in patients with chronic hepatitis C and this can lead to kidney damage.  The only way to tell is … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, Glomerulonephritis, Kidney-Related Health Questions, Laboratory Testing, Symptoms and Side Effects, Treatments