Category Archives: IgA Nephropathy/IgA Dominant Glomerulonephritis

To whom it may concern: I am writing this letter to ask you a question about my mother who has IgA nephropathy problem which has been continued for 8 years. Although, the rate of proteinuria raised nearly 3450 mg/24hrs last year and her Dr. prescribed prednisolone 50 at first. As a result, rate of proteinuria has decreased to 194 mg/24 hrs. On order to her Doctor was able to decline prednisolone to 12.5 mg/day. Despite decreasing of protein rate in urine, the amount of proteinuria has raised again to 1710 mg/24hrs! So her Doctor raised prednisolone to 15 mg/day. In addition, she uses Calcitriol in their medication as well. I want to know that it is important to follow treatment by using of prednisolone after one year so as to use constantly? I really worry about the side effect of using this drug extra for my Mother!

The goal of treating IgA Nephropathy is to lower the protein in the urine and improve kidney function.  It sounds like your mother is being treated appropriately.  Your mother’s physician should be monitoring the side effects of prednisolone.  The side … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, Diabetes, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions, Laboratory Testing, Medication and Kidney Disease, Medication and Kidney Function, Nephrologist, Symptoms and Side Effects, Treatments

My father is suffering from IgA nephropathy for last two years. His present blood creatinine is 2.1mg/dl. Our doctor is only giving him MEGA-3 medicine and some medicine for blood pressure. His current B.P is 130/80. I want to ask that treatment is going in right way or not?

There is no specific treatment for IgA nephropathy.  Treatment of high blood pressure and in some cases the use of fish oil has been recommended.  Other treatments are used only if there is progressive loss of kidney function or large … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, IgA Nephropathy/IgA Dominant Glomerulonephritis

I have IgA nephropathy (gfr 55). I have dry eyes and have been searching for some type of remedy for some time. Recently a new medication has come to market by the name of Xiidra. My opthamologist has prescribed it for me and I have just started to use these eye drops? I am wondering if this medication or any other eye drops can potentially harm my kidney function?

I do not know of any ill effects of eye drops on kidney function.  I am not familiar with Xiidra, but kidney injury is not listed as a concern for the medication. For more information on IgA click here:

Posted in Ask the Doctor, Chronic Kidney Disease, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions, Medication and Kidney Disease, Treatments

My son has IgA Nephropathy (stage 3b brought down from stage 4) and is currently on a conservative treatment (Losartan and a direutic) plan that has significantly brought down his proteinuria and hematuria (trace). My concern is if he should be taking any other medicines that directly treat his condition. I read that with stage 4 (egfr less than 30) no additional treatments are given but now that he has been in stage 3 for nearly a year should he be getting any additional treatments?. I recently read about the completion of a clinical trial for Rituximab for progressive IGAN. Is this drug now available for treatment for IGAN? Or are there any other treatment options in addition to the blood pressure medicines that he is currently on. Many thanks.

Rituximab (Rituxan) is not approved by the Food and Drug Administration (FDA) for the treatment of IgA nephropathy.  There have been many treatments proposed for IgA nephropathy, but no specific treatment has shown remarkable success.  Hence, it is best that … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, GFR, IgA Nephropathy/IgA Dominant Glomerulonephritis

I have been suffering from IgA nephropathy since four years. Can you please suggest daily diet & exercise plan? Is there any medication for this disease? What is immunotherapy? When should I go for dialysis or kidney replacement? Please send your views as soon as possible. Is they any cure for it in USA?

There is no cure for IgA nephropathy in the USA or anywhere in the world.  I suggest that you consult with a nephrologist in your country and ask for advice.  IgA nephropathy has many different symptoms and has many different … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions, Nephrologist

Thank you for your response regarding my son’s the elevated PTH level of 110 ( three months back this was 57). Yes, my son has IGA Nephropathy and CKD stage 3. All other results are normal. His doctor is of the view that we need not do anything in this regard. He currently takes over the counter Vitamin D which his doctor says he could continue. However, I read on this site (National Kidney Foundation) that this should be treated with special vitamin D and not over the counter Vitamin D. (His vitamin D, calcium and phosphorus levels are all normal) Your guidance in this regard will be very helpful.

Patients with chronic kidney disease (CKD) commonly have an elevated parathyroid hormone (PTH) level.  This is known as secondary hyperparathyroidism, and in general is treated by keeping the phosphorus level and calcium level in the normal range, using vitamin D … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, GFR, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions, Treatments

I have recently a number of studies (NIH website) that show good benefits of Gum Arabic for CKD patients. Is this safe for IGA CKD stage 3 patients?

I am not familiar with the benefits of “Gum Arabic” for any treatment of chronic kidney disease (CKD).  I know of no benefits for such treatment. For more information on IgA click here: For more information on Chronic Kidney Disease … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions

Thank you for your response to my earlier questions. Just today I read about this potential treatment for IGAN using IGAN Protease. This is really promising. Do you have any further information on this. http://jasn.asnjournals.org/content/early/2016/02/04/ASN.2015080856.abstract https://sbir.nih.gov/sites/default/files/CAP_PDFs/IGAN.pdf

This study was done in mice and has not been tested in humans.  As I said before, the most important aspect of clinical research is to make sure that a treatment is safe in humans.  Hence, this treatment has not … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions

My son (28 years old) had high blood pressure (200/150) last year (April 2015) and further examination showed that he had large blood and protein in his urine and his blood creatinine was 3.3. The biopsy of one of the kidneys showed that he had IGA and ‘if the sample is true for the whole kidney than he had stage 4 CKD. However, over the last year (May 2016) his results showed marked improvement. Proteinuria is now negative, and blood in urine is small and creatinine is 2.3. The BUN is normal (23). And Vitamin D and Hemoglobin and all other indicators are normal or within range. He has no other symptoms. He has been taking Losartan 100mg and a diuretic 25mg. His blood pressure is normal (120-130/80-85). He has, through dieting, lost about 35 pounds and does not add any salt to his food. The eGFR calculation is currently based on serum creatinine and does not include CystatinC. How is that test done? And what according to you is his prognosis and what more can he do to preserve his kidney function?

IgA nephropathy is a common kidney disease that can cause blood and protein in the urine and can also cause chronic kidney disease (CKD).  It sounds like your son has been appropriately treated and should continue to follow with the … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, GFR, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions

As per my doctor and test, I have been diagnosed as IGA Nephropathy. Now I am taking medicine Eritel-40, Maxepa. Similarly my uric acid is high hence I am taking medicine Febutaz and Endocap. Please suggest if these medicines are good to proceed or anything else I can do here.

IgA nephropathy is a common kidney disease that commonly causes blood and protein in the urine and may cause progressive chronic kidney disease (CKD).  The treatments that you mention are commonly used.  I cannot recommend treatment without performing a complete … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions, Treatments