Category Archives: IgA Nephropathy/IgA Dominant Glomerulonephritis

Hi. I am 31 F. I have been feeling rotten recent month. Then had an infection so had my bloods done. They showed an iron deficiency, anemia as well as infection. My Hgb was 10.3 ferritin 6.9. I have been taking oral iron before this too. My creatinine was 1.61, Ur 11.7, eGFR 40. Thinking is likely to be IgA nephopathy. They thought would be periods, although mine are light and short. Last had check, last year my Hgb was 13.5. Do you think it is relevant to the kidney check and what options are there to improve the anemia? Thanks.

Kidney disease and anemia commonly occur together. The kidney is responsible for making a hormone known as erythropoietin. This hormone helps to make red blood cells. In patients with acute or chronic kidney disease, anemia is very common. It is … Continue reading

Posted in Acute Kidney Injury, Anemia, Ask the Doctor, Chronic Kidney Disease, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney Biopsy, Kidney-Related Health Questions

How do I know what stage of CKD I am? I was just diagnosed with IgA Nephropathy and Secondary FSGS.

You will need to know your serum creatinine and then use this value to calculate your estimated glomerular filtration rate (eGFR). The eGFR is then used to categorize your stage of chronic kidney disease (CKD). You can review the calculation … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, GFR, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions

My friend has Berger’s and I was curious about what would happen if someone with IgA deficient blood gave him a transfusion? Or transplant? Would it decrease the build up in his own kidneys ‘naturally’? I really am curious if this is an avenue researched have looked into… We both grew up in the same environmental area and attended the same school. I’ve always felt like I should donate my kidney, but my doctor has said not because of the IgA issue I have. I have IgA deficient, O positive blood.

The problem in IgA nephropathy (which is also known as Berger’s Disease) has to do with the abnormal way of making IgA so that the molecule is damaged. Someone with IgA nephropathy has a tendency to make abnormal IgA molecules … Continue reading

Posted in Ask the Doctor, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney Failure, Kidney-Related Health Questions, organ donation, Transplantation

I wanted to ask your opinion on the supplements acetyl l carnitine and alpha lipoic acid used for pain control in those with neuropathy. I have IGA neuropathy and my last GFR (Oct. 2018) was 51.

Carnitine has been studied in the treatment of anemia associated with dialysis patients. Alpha lipoic acid has been advocated for the treatment of painful neuropathy associated with diabetes. I am not aware of any studies done with either of these … Continue reading

Posted in Anemia, Ask the Doctor, Diabetes, Dialysis, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions

I am suffering from IgA nephropathy since I was 17, now I am 35, currently in stage 3 CKD. I am currently taking omega 3 fatty acids and Losartan 50mg. Due to shortness of breath and lack of sleep, my doctor has advised to stop Losartan. So, I am now only taking omega 3. Could you please advise on this as this is the first time I am stopping Losartan over these years? The blood tests are Albumin ++ and creatinine 1.4.

The standard treatment of IgA nephropathy has been to use ACE inhibitors or ARB agents with or without fish oil. Losartan is an ARB agent. In some cases, prednisone and immunosuppression has been recommended but there are no clear cut … Continue reading

Posted in Ask the Doctor, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions, Nephrologist

Doctor, my wife is diagnosed with IgA +3 Disease and advised to take steroids. Her current B/P is 140/90 and proteinuria 4+. Please advise whether steroids are must to take or we can go for alternative medicines?

The use of blood pressure agents such as ACE-inhibitors and ARB agents are most commonly recommeded in patients with Immunoglobuliln A (IgA) nephropathy. Corticosteroids, such as Prednisone or Dexamethasone are also commonly used depending on characteristics found on the kidney … Continue reading

Posted in Ask the Doctor, Hypertension/High Blood Pressure, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney Biopsy, Kidney-Related Health Questions

I a 48 year old caucasian male, diagnosed with Stage 3 CKD in 2017, biopsy confirmed IgAN in January of this year, was started on Prednisone and SoluMedrol for 6 months. With two more weeks of Prednisone treatment. For the first time in 18 months I have no Hemoglobin or RBC in my urine. However, my creatinine level has remained around 1.6 and my GFR is 47, it was 46 at the beginning of treatment in January. Is the resolving of hematuria (given no appreciable improvement in GFR) reason to celebrate? Or with no improvement in GFR has Prednisone not worked for me? I have not had an issue spilling protein, until I convinced my nephrologist to allow me to suspend Lisinopril for 2 months. Once I restarted the 10mg of Lisinopril my protein spillage resolved. I have read that hematuria and proteinuria are bad prognostic predictors for progression of IgAN towards ESRD. I remain hopeful with these resolved, however am confused why my eGFR or creatinine are not also showing improvement.

In the case of glomerulonephritis and in the specific case of Immunoglobulin A nephropathy (IgA nephropathy), once glomeruli have been destroyed by disease, it may not be possible to repair old ones and it is NOT possible to build new … Continue reading

Posted in Ask the Doctor, GFR, Glomerulonephritis, Hematuria, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions, Proteinuria

My sister (34 yrs) is recently diagnosed with IGA Nephropathy (M1 E1 S0 T1 C1) with focal crescents based on biopsy. She was put on Solumedrol 500mg (3 doses completed by 22nd March) then started on following medications: a. T Defstead 30mg 1-0-0 b. T Mystead 500mg 1-0-1 c. Zyloric 100mg 0-0-1 d. Shelcal 500mg 1-0-1 e. Maxepa 1-1-1 f. Amlong 5mg 1-0-1 g. Rantac 1-0-1. This controlled her Cr to 3.1 for 2 months and then again started increasing. It has increased to 4.1 now and doctor is suggesting for dialysis/transplant. The doubt I have is, she urinates a lot however one of the symptom of IGA nephropathy is less urination. Is she in good hands? Please suggest.

Urine volume is not a good indicator of kidney function. Kidney disease, including IgA nephropathy, causes a decrease in the estimated glomerular filtration rate (eGFR), but it does not usually cause a change in urine volume. I suggest that your … Continue reading

Posted in Ask the Doctor, GFR, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions

I have IgA N, diagnosed in 1992 with a biopsy. So far I am doing fine and my test results are normal. Is it possible for IgAN to stay stable or go away?

IgA nephropathy is a very unpredictable type of kidney disease. If you have high blood pressure or if you are spilling large amounts of protein into your urine, this will often predict a more aggressive course for the disease. If … Continue reading

Posted in Ask the Doctor, Hypertension/High Blood Pressure, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions

Do you have any insight on Loin Pain Hematuria and its correlations with IGa Nephropathy?

Loin Pain Hematuria syndrome is a collection of symptoms that include microscopic and rare macroscopic blood in the urine (hematuria) associated with bouts of flank and back pain but the kidney is normal on biopsy. With IgA nephropathy, blood can … Continue reading

Posted in Ask the Doctor, Hematuria, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney Biopsy, Kidney-Related Health Questions, Proteinuria