Category Archives: IgA Nephropathy/IgA Dominant Glomerulonephritis

Doctor, my wife is diagnosed with IgA +3 Disease and advised to take steroids. Her current B/P is 140/90 and proteinuria 4+. Please advise whether steroids are must to take or we can go for alternative medicines?

The use of blood pressure agents such as ACE-inhibitors and ARB agents are most commonly recommeded in patients with Immunoglobuliln A (IgA) nephropathy. Corticosteroids, such as Prednisone or Dexamethasone are also commonly used depending on characteristics found on the kidney … Continue reading

Posted in Ask the Doctor, Hypertension/High Blood Pressure, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney Biopsy, Kidney-Related Health Questions

I a 48 year old caucasian male, diagnosed with Stage 3 CKD in 2017, biopsy confirmed IgAN in January of this year, was started on Prednisone and SoluMedrol for 6 months. With two more weeks of Prednisone treatment. For the first time in 18 months I have no Hemoglobin or RBC in my urine. However, my creatinine level has remained around 1.6 and my GFR is 47, it was 46 at the beginning of treatment in January. Is the resolving of hematuria (given no appreciable improvement in GFR) reason to celebrate? Or with no improvement in GFR has Prednisone not worked for me? I have not had an issue spilling protein, until I convinced my nephrologist to allow me to suspend Lisinopril for 2 months. Once I restarted the 10mg of Lisinopril my protein spillage resolved. I have read that hematuria and proteinuria are bad prognostic predictors for progression of IgAN towards ESRD. I remain hopeful with these resolved, however am confused why my eGFR or creatinine are not also showing improvement.

In the case of glomerulonephritis and in the specific case of Immunoglobulin A nephropathy (IgA nephropathy), once glomeruli have been destroyed by disease, it may not be possible to repair old ones and it is NOT possible to build new … Continue reading

Posted in Ask the Doctor, GFR, Glomerulonephritis, Hematuria, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions, Proteinuria

My sister (34 yrs) is recently diagnosed with IGA Nephropathy (M1 E1 S0 T1 C1) with focal crescents based on biopsy. She was put on Solumedrol 500mg (3 doses completed by 22nd March) then started on following medications: a. T Defstead 30mg 1-0-0 b. T Mystead 500mg 1-0-1 c. Zyloric 100mg 0-0-1 d. Shelcal 500mg 1-0-1 e. Maxepa 1-1-1 f. Amlong 5mg 1-0-1 g. Rantac 1-0-1. This controlled her Cr to 3.1 for 2 months and then again started increasing. It has increased to 4.1 now and doctor is suggesting for dialysis/transplant. The doubt I have is, she urinates a lot however one of the symptom of IGA nephropathy is less urination. Is she in good hands? Please suggest.

Urine volume is not a good indicator of kidney function. Kidney disease, including IgA nephropathy, causes a decrease in the estimated glomerular filtration rate (eGFR), but it does not usually cause a change in urine volume. I suggest that your … Continue reading

Posted in Ask the Doctor, GFR, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions

I have IgA N, diagnosed in 1992 with a biopsy. So far I am doing fine and my test results are normal. Is it possible for IgAN to stay stable or go away?

IgA nephropathy is a very unpredictable type of kidney disease. If you have high blood pressure or if you are spilling large amounts of protein into your urine, this will often predict a more aggressive course for the disease. If … Continue reading

Posted in Ask the Doctor, Hypertension/High Blood Pressure, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions

Do you have any insight on Loin Pain Hematuria and its correlations with IGa Nephropathy?

Loin Pain Hematuria syndrome is a collection of symptoms that include microscopic and rare macroscopic blood in the urine (hematuria) associated with bouts of flank and back pain but the kidney is normal on biopsy. With IgA nephropathy, blood can … Continue reading

Posted in Ask the Doctor, Hematuria, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney Biopsy, Kidney-Related Health Questions, Proteinuria

I have just been diagnosed with IgA nephropathy (although they have not yet confirmed the diagnosis via biopsy). Could you let me know what the normal prognosis is?

The only way to make a specific diagnosis of IgA nephropathy is to perform a kidney biopsy.  IgA nephropathy has many different clinical courses and manifestations.  The biopsy information also results in important features that suggest prognosis.  Hence, if a … Continue reading

Posted in Ask the Doctor, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions

I am a relatively healthy 30 year-old female, who was randomly sent to the hospital in September to discover I had a kidney condition. In the hospital, my kidney function was about 10-15%. After biopsy, it was decided that I have IgA nephropathy. Since then, my kidney function has been testing normal, however I tend to feel fatigued, get headaches (migraines), trouble concentrating, sometimes nauseous or lack of appetite, also back aches. Overall I just don’t feel “right.” I was put on Benazepril, but stopped because my blood pressure has been normal. I have been seeing a nephrologist, nutritionist, and my primary care physician, all of which say different things. Do you recommend any other tests or procedures to have done to dive a little deeper?

IgA nephropathy is a relatively common kidney disease that commonly results in blood and protein showing up in the urine.  Benazepril or other ACE-inhibitors are commonly used to treat the disease.  The Benazepril or other ACE-inhibitors are used even if … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions, Medication and Kidney Function

I have IgA nephropathy stage 3A. I have been prescribed by a specialist Diclofenac Sodium Topical 1% gel for severe burning pain in my feet caused by neuropathy.  I am not sure what it contains but I think it is in the NSAID family.  I am well aware of your guidance not to use these types of pain medications but I wonder if a topical application would be any safer

The topical use of non-steroidal anti-inflammatory drugs (NSAID’s) such as Diclofenac is generally considered safe for patients with chronic kidney disease (CKD).  The amount that is absorbed into the blood is very small when used topically.

Posted in Ask the Doctor, Chronic Kidney Disease, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions, Medication and Kidney Disease

I have been suffering IgA nephropathy about 30years. I am now 49 years woman. My disease is not severe, just protein and hematuria in my urine. I have ACE medicine, for keeping my blood pressure solid because I have no high pressure. I have read studies where it’s said, that they have found diet without gluten (maybe dairy and red meat too) has been useful and protein has decreased and the glomerulus has gotten better. Is it worth it to leave gluten and maybe dairy and red meat out on diet to help my kidneys?

There are many theories about the cause of IgA nephropathy that include dietary causes such as gluten and other foods in the diet (as you mention). These remain theories because no study has yet shown that adjusting the diet in … Continue reading

Posted in Ask the Doctor, Diet/Nutrition, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions, Proteinuria

I was diagnosed with Chronic Hep B over 16 years now. But no treatment of any sort has been taking because of no incident. I have to do LFT and kidney function test which I recently did and the result showed that my plasma creatinine was high 145mmol/L and total Bilirubin 31mmol/l. I am already in consultation with a gastroenterologist who asked me to do more test, which I have done and waiting for result. (Viral load, serum alpha fp, Hep BeAg and Hep BeAb). I commenced Livolyn Forte yesterday while I wait for the outcome of the results. So what treatment do you think I should start with because of the high creatinine. Thank you.

Chronic hepatitis B is associated with several kidney diseases including cryoglobulinemia, vasculitis, IgA nephropathy, membranous nephropathy and membranoproliferative glomerulonephritis. I am unable to make a specific diagnosis based on the information that you present. I am unable to recommend treatment … Continue reading

Posted in Ask the Doctor, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions