Category Archives: IgA Nephropathy/IgA Dominant Glomerulonephritis

I am male, 30 years old and I have Proteinuria. Doctors suspect some kind of Glomerulonephritis. One doctor thinks is IgA Nephropathy. And I am really confused and worried. I decided to do a biopsy to find out in about a month from now. The laboratory results are confusing me a bit as they use different measurements. All are urine test results here. January 2017: Urinary Micro Albumin: 1132 mg/L Urinary Creatinine: 1.25 gm/L Albumin Creatinine Ratio (ACR) 905.0 mg/gm February 2017: Urinary Micro Albumin: 590 mg/L Urinary Creatinine: 0.60 gm/L Albumin Creatinine Ratio (ACR) 983.0 mg/gm May 2017: Urinary Albumin: 109.2 mg/dL Urinary Creatinine: 0.08 g/dL Albumin Creatinine Ratio (ACR) 1365 mg/g (Different laboratoy than the 2 previous) I will appreciate a lot if you kindly would give me your feedback.

The only result that you quote consistently is the urinary albumin to creatinine ratios.  The other results reflect the concentration of the urine and are not significant.  The urinary albumin to creatinine ratios are between 905 and 1365.  These numbers … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, Hydronephrosis and Hydroureter, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney Biopsy, Kidney-Related Health Questions, Laboratory Testing, Nephrologist

My friend was diagnosed with IgA nephropathy stage 3 about 1 yr ago. His current function is 24, taking predisone along with hypertension medication. What is his kidney risk for failure? He is 68 yrs old. Thank you.

I am unable to provide a prognosis without performing a complete history and physical examination.  The best person to ask this is his nephrologist, who knows his prior history and can perform a physical examination. For more information on IgA … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions, Laboratory Testing, Treatments

Hi Doctor, My partner was diagnosed 5 years ago, at the age of 26, with a rare Kidney disease called mesangial capillary glomerulonephritis. He has been on steroid treatment and also cholesterol, blood pressure and other pills. He has suffered with many side effects including depression, mood swings, frequency of urination, dizziness, blurred vision and most recently the beginnings of osteoporosis. I have heard of Chinese Medicine Osmotherapy and read about some studies on www.ncbi.nlm.nih.gov and it seems very effective in treating patients with IgA nephropathy. I was wondering if you think this might work for my partner too? and whether it could be used in conjunction with his current medications? My second question is how likely do you think it would be for us to pass this disease down to a child? Thank you for any help you might give us… I worry about our future family and hope that someone will find a cure soon.

Mesangiocapillary glomerulonephritis (MCGN) is an uncommon kidney disease.  There are many different forms of MCGN that have been described.  Chinese medical osmotherapy is of no benefit in any kidney disease that I am aware. I cannot comment on whether you … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, Glomerulonephritis, Hypertension/High Blood Pressure, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions, Laboratory Testing, Medication and Kidney Disease, Nephrologist, Pregnancy / Kids, Symptoms and Side Effects, Treatments

I have been diagnosed with IgA nephropathy and is in stage 3 CKD. My question is related to diet. I have observed from experience that if I follow a low protein diet, my egfr and creatinine seems to be in better level. When I increase food intake there is a decrease in egfr and increase in creatinine levels. My nephrologist insists not to worry about diet or protein at this stage. Is it better to take less food and be underweight or is it better to take enough food and worse the blood results?

I agree with your physician.  I am not a fan of low protein diets.  This can lead to malnutrition which can have other ill effects on your body.  I suggest that you follow a low salt DASH diet.  You can … Continue reading

Posted in Chronic Kidney Disease, Diet/Nutrition, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions, Treatments

To whom it may concern: I am writing this letter to ask you a question about my mother who has IgA nephropathy problem which has been continued for 8 years. Although, the rate of proteinuria raised nearly 3450 mg/24hrs last year and her Dr. prescribed prednisolone 50 at first. As a result, rate of proteinuria has decreased to 194 mg/24 hrs. On order to her Doctor was able to decline prednisolone to 12.5 mg/day. Despite decreasing of protein rate in urine, the amount of proteinuria has raised again to 1710 mg/24hrs! So her Doctor raised prednisolone to 15 mg/day. In addition, she uses Calcitriol in their medication as well. I want to know that it is important to follow treatment by using of prednisolone after one year so as to use constantly? I really worry about the side effect of using this drug extra for my Mother!

The goal of treating IgA Nephropathy is to lower the protein in the urine and improve kidney function.  It sounds like your mother is being treated appropriately.  Your mother’s physician should be monitoring the side effects of prednisolone.  The side … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, Diabetes, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions, Laboratory Testing, Medication and Kidney Disease, Medication and Kidney Function, Nephrologist, Symptoms and Side Effects, Treatments

My father is suffering from IgA nephropathy for last two years. His present blood creatinine is 2.1mg/dl. Our doctor is only giving him MEGA-3 medicine and some medicine for blood pressure. His current B.P is 130/80. I want to ask that treatment is going in right way or not?

There is no specific treatment for IgA nephropathy.  Treatment of high blood pressure and in some cases the use of fish oil has been recommended.  Other treatments are used only if there is progressive loss of kidney function or large … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, IgA Nephropathy/IgA Dominant Glomerulonephritis

I have IgA nephropathy (gfr 55). I have dry eyes and have been searching for some type of remedy for some time. Recently a new medication has come to market by the name of Xiidra. My opthamologist has prescribed it for me and I have just started to use these eye drops? I am wondering if this medication or any other eye drops can potentially harm my kidney function?

I do not know of any ill effects of eye drops on kidney function.  I am not familiar with Xiidra, but kidney injury is not listed as a concern for the medication. For more information on IgA click here:

Posted in Ask the Doctor, Chronic Kidney Disease, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions, Medication and Kidney Disease, Treatments

My son has IgA Nephropathy (stage 3b brought down from stage 4) and is currently on a conservative treatment (Losartan and a direutic) plan that has significantly brought down his proteinuria and hematuria (trace). My concern is if he should be taking any other medicines that directly treat his condition. I read that with stage 4 (egfr less than 30) no additional treatments are given but now that he has been in stage 3 for nearly a year should he be getting any additional treatments?. I recently read about the completion of a clinical trial for Rituximab for progressive IGAN. Is this drug now available for treatment for IGAN? Or are there any other treatment options in addition to the blood pressure medicines that he is currently on. Many thanks.

Rituximab (Rituxan) is not approved by the Food and Drug Administration (FDA) for the treatment of IgA nephropathy.  There have been many treatments proposed for IgA nephropathy, but no specific treatment has shown remarkable success.  Hence, it is best that … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, GFR, IgA Nephropathy/IgA Dominant Glomerulonephritis

I have been suffering from IgA nephropathy since four years. Can you please suggest daily diet & exercise plan? Is there any medication for this disease? What is immunotherapy? When should I go for dialysis or kidney replacement? Please send your views as soon as possible. Is they any cure for it in USA?

There is no cure for IgA nephropathy in the USA or anywhere in the world.  I suggest that you consult with a nephrologist in your country and ask for advice.  IgA nephropathy has many different symptoms and has many different … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions, Nephrologist

Thank you for your response regarding my son’s the elevated PTH level of 110 ( three months back this was 57). Yes, my son has IGA Nephropathy and CKD stage 3. All other results are normal. His doctor is of the view that we need not do anything in this regard. He currently takes over the counter Vitamin D which his doctor says he could continue. However, I read on this site (National Kidney Foundation) that this should be treated with special vitamin D and not over the counter Vitamin D. (His vitamin D, calcium and phosphorus levels are all normal) Your guidance in this regard will be very helpful.

Patients with chronic kidney disease (CKD) commonly have an elevated parathyroid hormone (PTH) level.  This is known as secondary hyperparathyroidism, and in general is treated by keeping the phosphorus level and calcium level in the normal range, using vitamin D … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, GFR, IgA Nephropathy/IgA Dominant Glomerulonephritis, Kidney-Related Health Questions, Treatments