Category Archives: Kidney Biopsy

I have CKD; right now my gfr is 23, 3 months ago it was 35. What caused the big drop? Can’t seem to get an answer from my nephrolgist, except he’s seen bigger drops and he’s not concerned. Originally 3 years ago GFR did the same thing from 56 – 32 in a month’s time. I thought is was slow progression. I watch my diet, exercise, do not have diabetes, have controlled BP. I do have protein and microscopic blood in urine. I am overweight (about 25 pds). I am working on that. I feel I am doing everything I can and these big drops are scaring me. My Mom (deceased) and older sister both have CKD as well. I’m 65, my Mom was in her 80’s when she started dialysis. My sister is Stage 4 and has been stable for 4 years. I just can’t seem to figure out why my kidney function is declining so rapidly. Can you help me understand?

I am not able to make a specific diagnosis based on the information that you present. Since your mother and sister both have kidney disease, it could be that you have a hereditary kidney disease. In order to know this, … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, Glomerulonephritis, Hypertension/High Blood Pressure, Kidney Biopsy, Kidney-Related Health Questions

Good day Doctor. I am 42 years old, 190 cm tall and 82 Kg. My serum creatinine has been changing between 1.19 and 1.36 mg/dl for the last two years. No diabetes, blood pressure 120/70 in the morning, 130/80 before going to bed. Kidney ultrasonography shows everything OK. ACR is 1.4 mg/g. I was diagnosed with CKD stage 2, with a non specified origin. Any advice about which test should I take to know what exactly is wrong with my renal function and what should I do to avoid further damage? Thank you.

I cannot identify the basis of your diagnosis of Stage 2 chronic kidney disease. You will need to clarify this with the physician who made this diagnosis. In some cases, the only way to definitively establish a diagnosis of kidney … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, GFR, Kidney Biopsy, Kidney-Related Health Questions

My father is a kidney patient, he was transplanted on 2015. Now on 6.5.2020, we got a urine report that says protein is released in his urine. Why is that? And what is his condition now? Can you please explain?

The normal amount of protein in the urine is less than 150 to 200 milligrams per day or less than 0.15 to 0.20 milligrams of protein per milligram of creatinine. The loss of excessive protein in the urine suggests that … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Kidney Biopsy, Kidney-Related Health Questions, Serum Creatinine, Transplantation

I am a 27 year old male from India. I am on a kidney treatment by Ayurveda medicine from Delhi. The past 3 months I’ve been following an almost all strict diet but my creatinine level is not lowering as it should be. I always feel nausea throughout the day, lower hunger, and legs get swollen. Please advise.

I am unable to make a specific diagnosis based on the information that you present. In order to recommend treatment, I would need to perform a complete history and physical examination. Only by making a specific diagnosis, can you make … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, Kidney Biopsy, Kidney-Related Health Questions, Nephrologist

Hello. How are you, sir? My mother is a kidney patient. Age 65 years. 11 years ago her creatinine was 11, urea nitrogen above 100, vomiting and urine problems also. She went to dialysis for one year. After 1 year of dialysis, she was recovered and creatinine was about 3 to 4 and urea about 30 to 70. After 10 years, she now has a creatinine of 11, feeling tired and urea 70. She is not vomiting and does not have urine problems; but she is feeling ill. The fistula in her arm was made 11 years ago and is working. The Doctor in Pakistan has recommended that she starts dialysis. I want to know whether she should start dialysis or needs to wait? If you can give your whastapp, I can send you the complete reports as well. Please give me your recommendations. Waiting for you reply. Thanks.

I am unable to make a specific diagnosis based on the information that you present. It does appear that your mother has advanced kidney disease, but I am unable to perform a complete history and physical examination in order to … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, Kidney Biopsy, Kidney-Related Health Questions

Dear sir, I am a kidney patient. Last year July 2019 my transplant operation was done. My wife donated her kidney to me. My blood group is A+ as my wife. My treatment was going well till October, but in October my TLC suddenly started dropping and my creatinine started to increase. At that time my medicines were: Tacloran 2.5 BD, Mycoral 720 BD, Amplodipine 10mg BD, Wysolone 10mg morning and Arcamine 100mcg BD. After some time, the doctor advised me for a kidney biopsy. In the biopsy report they found Grade I Chronic Active T-cell mediated rejection. Now my creatinine is increased to 5.5, my TLC again dropped to 1920/cu.mm. The Dr. advised me to take injection Filgrastim/grafeel 300mcg to increase TLC and advised dialysis in future. Sir, is there any hope to save my current kidney transplant or any other treatment to save my kidney? Please advise. With best regards.

Your kidney biopsy suggests that you have chronic rejection. Your transplant physician will have to recommend treatment for chronic rejection. Chronic rejection is very difficult to treat and in many cases, it does not respond to treatment. I am unable … Continue reading

Posted in Ask the Doctor, Kidney Biopsy, Kidney-Related Health Questions, Transplantation

My husband is now 28 yrs old. Before the age of 5, he had a kidney transplant. His mother was the donor. Until 2019, his creatinine was 3 but it has suddenly risen to 5.5 now. Can we decrease his creatinine level now? He is feeling chest pains at night, swelling in the legs, etc.

This is a serious problem for his kidney transplant and requires that he see his transplant physician as soon as possible. I am unable to make a specific diagnosis based on the information that you present. He needs to be … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Kidney Biopsy, Kidney-Related Health Questions, Laboratory Testing, Transplantation

Hi Dr. Spry, My wife has Nephrotic Syndrome disease. We discovered in Feb. 2017 and her 24HR URINE PROFILE result was 4180. She used “Cellcept” and her result was still very high. It’s 2400. Is there any other medicine to get the best result? I appreciate it. Thanks.

Treatment of nephrotic syndrome usually requires that a kidney biopsy is performed. Treatment is based on a specific diagnosis and a specific diagnosis requires a kidney biopsy. If your wife has not had a kidney biopsy, I suggest one be … Continue reading

Posted in Ask the Doctor, Kidney Biopsy, Kidney-Related Health Questions, Nephrologist, Nephrotic Syndrome

I am 31 years old. My serum creatinine level is increasing day by day. My serum creatinine is 5.38. Now I wanted to know how could I reduce my serum creatinine?

You will need to see a nephrologist and have further testing. In order to treat kidney disease you will need a specific diagnosis as to the cause of your kidney disease and this will lead to specific treatment. If you … Continue reading

Posted in Acute Kidney Injury, Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, Kidney Biopsy, Kidney-Related Health Questions, Nephrologist, Serum Creatinine

Hello, I am a 34 year old female. Found out I had a kidney disease during pregnancy. I have hematuria and proteinuria (last measurement 4 gram/24 hour, often between 2,5-4 grams per 24 hours – never nephrotic syndrome). One biopsy done, no autoimmune disease but it says: glomerular hypertrophy, glomerulosclerosis, hyperfiltration, some IF/TA and arteriolar hyalinosis. No diabetes and all blood sugar levels are normal. Serum albumin around 37, creatinine around 85, egfr around 85. I am overweight, but not morbidly obese. I have hypertension and I’m currently being treated with two different types of medicines. Can you say anything about which disease I might have? And what is my risk of progressing to ESRD? Thank you.

The kidney biopsy that you quote sounds like Focal Segmental Glomerulosclerosis (FSGS). It is a scaring disease of the kidney. You can review information about FSGS on our web site at: https://www.kidney.org/atoz/content/focal I am unable to offer a prognosis without … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, FSGS, Kidney Biopsy, Kidney-Related Health Questions, Nephrologist