Category Archives: Laboratory Testing

Test Report Beta-2 Microglobulin (ß2M) has been identified as the light chain of the HLA-A, -B, and -C major histocompatibility complex antigens, 100 amino acids in length and noncovalently associated with the heavy chain. ß2M occurs on the surface of nucleated cells- abundantly on lymphocytes and monocytes- and on many tumor cell lines. Its function is unknown, but it may control the expression and on the cell surface. Elevated serum concentrations in the presence of a normal glomerular filtration rate suggest increased ß2M production or release. What does this test report of myeloma panel mean? This is the report of patient suffering from chronic kidney disease.

Beta-2-microglobulin can be elevated in patients with chronic kidney disease (CKD) and is often elevated in patients with multiple myeloma. It be elevated in some patients with lymphoma and leukemias. For interpretation, you will have to consult with the physician … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, Kidney-Related Health Questions, Laboratory Testing

Sir, we are going for kidney transplant and want to know what are the test to be done of donor and recipient and how much the results have to be to match? Please send me reply. I shall be very pleased. Thank you.

The testing required for a kidney transplant varies with the transplant center, but in general requires ABO blood type matching, HLA-A, HLA-B and HLA-D testing, as well as cross-matching. In some laboratories, Anti-HLA testing and Panel Reactive Antibody (PRA) testing … Continue reading

Posted in Ask the Doctor, Donation, Kidney-Related Health Questions, Laboratory Testing, Nephrologist, Transplantation

Our daughter has kidney stones, and the Dr. says, both kidneys are full of stones. For a period of time she was able to pass the stones, but now she is not passing them. The Dr. is doing another 24 hr urinalysis study, and the same test that any urologist would perform. He is stumped. Would it be to our advantage to seek further treatment from a Doctor that specializes in kidney disease? Her father is a pharmacist, and has suggested for some time our need for someone that can help her. Our fear is that her kidneys will fail and she will go on dialysis. She is 41.

I am not able to make a specific diagnosis based on the information that you present. There are many causes of recurrent and chronic kidney stones. The urologist is the person who is most likely to make a proper diagnosis … Continue reading

Posted in Ask the Doctor, Kidney Stones, Kidney-Related Health Questions, Laboratory Testing, Nephrologist, Urological Issues

Recently I got to know that I am having umbilical hernia and pre operative checkup for kidney shows my creatinine level is 1.54 and it is flactuating one day it was 1.54 next day it was 1.23 and day after again it was 1.54. Recently get it checked again it was 1.15 next day 1.2 and again next day it was 1.54 and next day it was 1.2. I don’t have any medical history, I am a vegetarian and don’t eat any kind meat, don’t take any type alcohal or smoke. Don’t have any diabetes, swelling, no high BP, no issue while passing the urine. Blood urea is 21. Can you please suggest why it is happening?

I am unable to make a specific diagnosis of kidney disease based on the information that you present. I suggest that you see your primary care physician for further testing. You should also have a urine test for blood, protein … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Kidney-Related Health Questions, Laboratory Testing

I’ve been seeing a rheumatologist for pain and swelling in my hands. He recently put me on Celebrex and ordered blood work to check my kidneys three months from when I started taking them. I also have been on a generic form of Adderal. I had the blood work on 9/18 and here were the results. Estimated CRCL (CG) 49mL/min. It then states ” Moderate decrease in CRCL. 30-59 if Estimated CRCL chronically is in this range, this corresponds to stage 3 CKD. Received a letter from the Rheumatologist office and they said everything looked ok. It doesn’t look ok to me!! Back on 4/15 apparently I had the same test done by my family Doctor and it read 52mL/min. My question is, what can I do to prevent this from dropping any further? Apparently my family Doctor or the Rheumatologist doesn’t see to be concerned, but I am. I’m 51 in pretty good health, and I want to keep it that way. Thank you!

The laboratory results that you mention could be consistent with early Stage 3 chronic kidney disease (CKD). I am unable to make any further diagnosis based on the information that you present. I do suggest that you get urine testing … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, Laboratory Testing

I am a 68 y.o. white female. I have one kidney (not sure how long the other one was atrophied, as it was noticed incidentally on a sonogram) and there is a mass on it thought to be benign because it has shrunk in the past. My GFR was 49 in April, 49 in June, 41 in August and now 49 in September. My BUN was 19, 19, 31 and 24 , Creatinine 1.15, 1.10, 1.30 and 1.12. These tests were performed by my hematologist who is following me for this, as well as anemia. My hemoglobin in now up to 11 (no meds). My BP is well controlled averaging 120/70 (on Avapro and Amlodipine). I am not overweight (5’6, 136 lbs.). I did take Nexium in the past for about 10 yrs and am now trying to control acid reflux with Zantac prn. I have had idiopathic peripheral neuropathy (lower legs and feet) for about 18 yrs. I am not diabetic. My Hematologist and Internist both agree that this is nothing to be concerned about and that I just need to recheck this in about 3 months. I am told that my GFR is low partly because of my age. I’d like your opinion of this assessments, as I want to do all that I can to keep my kidney function normal. Thank you.

You appear to have early Stage 3 chronic kidney disease (CKD) based on the testing that you provide. I cannot tell why you have CKD. The creatinine testing and estimated glomerular filtration rates (eGFR’s) that you describe are probably not … Continue reading

Posted in Anemia, Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, GFR, Kidney-Related Health Questions, Laboratory Testing

I have had Stage 3 kidney disease for 5 years and recently was able to donate blood and I did it twice within the allowed time frame. I seen my PCP today for some weight gain that was fluctuating past 3 weeks of up to 3 or 4 pounds overnight. I donated last 4 weeks ago. I had a full exam and no solid answers as to the gain, barely any edema, rings tight but mainly abdomen bloated and full feeling. I told my PCP I had donated twice recently and he stated that was probably the reason for the gain. He explained that the fluid shifts would not be normal for me with the kidney disease. He offered to repeat my kidney labs but I just had that done last month and seen my Doctor also and all was stable. I then did some research and some places said those with kidney disease should not donate and it can change your stage of disease. I am now wondering if I should have my labs rechecked. Any thoughts?

The reason for not donating blood for patients with chronic kidney disease (CKD) is related to the anemia that is commonly seen in patients with late Stage 3 or Stage 4 CKD. If you are not anemic, then donating blood … Continue reading

Posted in Anemia, Ask the Doctor, Chronic Kidney Disease, Kidney-Related Health Questions, Laboratory Testing

Dr. Spry, I was diagnosed with multiple myeloma two years ago based upon a bone marrow test of greater than 35% plasma cells. They call it smoldering MM. I have my blood tested every 3 months and my concern is with recent numbers. My calcium has been low at 7.5, B12 is 1462. My intact PTH is 238 with norm range at 10-65. My EGFR was 70 two months ago and is now 59 from blood test two weeks ago. I read various info on this and it suggest that I have kidney failure. I’m taking vit D, calcium and Alendronate medication. I had a MRI of my parathyroids which was negative. So it appears this could be secondary hyperparathyroidism, which usually kidney failure is the cause. I see my endocrinologist next Wed and I welcome your comments. I forgot to mention that my urine creatinine level is normal and albumin in the urine is normal.

Multiple myeloma (MM) can be a cause of chronic kidney disease (CKD).  I am unable to make a specific diagnosis of CKD based on the information that you present. I cannot be sure if you have primary or secondary hyperparathyroidism … Continue reading

Posted in Ask the Doctor, GFR, Kidney Failure, Kidney-Related Health Questions, Laboratory Testing, Nephrologist

Hi – I have a non-specific chronic glomerular nephritis. My creatinine and BUN are within the normal range, but I have high proteinuria. My last 24 hr count totaled around 800 mg for proteinuria. I take enalapril and losartan. I am a 30 yr old with good health otherwise. I’m a runner and have signed up for my first marathon. I’m running 30-40 miles a week for training, which is higher than ever for me. Is this a bad idea with kidney disease? Should I just limit myself to lower mileage weeks/races? I don’t want to do further damage to my already slowly diminishing kidney function.

Physical activity, including marathon running, should not pose any threat to your kidneys as long as you maintain adequate hydration. As you train, you should weigh yourself before and after running. Adequate hydration would mean that you lose a small … Continue reading

Posted in Ask the Doctor, Kidney-Related Health Questions, Laboratory Testing, Proteinuria

I am a 65 yo white female. My eGFR has been consistently less than 60 for at least 4 years. It has been as low as 45 and as high as 56. My most recent result was 50 on May 1, 2017. My BP is on the low side (116/70 is typical). I have extreme GERD and have taken Protonix for more than 10 years. I also take Meloxicam for inflammatory arthritis. I have recently discontinued Plaquenil as my arthritis has improved. When I question my primary care physician, he says not to worry about the low eGFR. I can’t help but worry, though, when I see my lab results that say results in the 30-60 range indicate Stage 3 renal disease. Should I be concerned? Thank you.

The Meloxicam that you mention can decrease kidney function. I suggest that you visit with your physician about the abnormal kidney numbers. I cannot make a specific diagnosis based on the information that you present. If your estimated glomerular filtration … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, GFR, Kidney-Related Health Questions, Laboratory Testing