Category Archives: Medication and Kidney Disease

Will abandoning my NSAID help my kidney function? Background: I am a 59-year-old woman, thin, low to normal BP, no drinking, no smoking ever. Diagnosed with autoimmune ankylosing spondylitis in 1989–full blown. History of back problems in teens. Have been on relatively high dose NSAIDs since 1989, which is credited for my decent range of motion despite entheses in various places. My creatinine has been gradually going up and my GFR is now 54, Creatinine 93. Is this to be expected of someone my age? Is it too late to make a difference, to stop the NSAID?

The long term use of high dose non-steroidal anti-inflammatory drugs (NSAID’s) is associated with progressive chronic kidney disease (CKD). This is especially true when combined with acetaminophen (Tylenol) or phenacetin (analgesic powders). If you are seeing a decline in your … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, GFR, Kidney-Related Health Questions, Medication and Kidney Disease

I am a 60 year old Caucasian male, 180 lbs, who walks and attends gym regularly, non smoker, no alcohol but HIV+ virus non-detectable – on medication (triumeq tab for HIV+), atenolol (25mg) and Lipitor (10mg) all one per day. My eGFR has gone from 53 in May of 2015 with ups and downs to 42 in September of this year. Creatinine in the same period increased from 1.36 to 1.65. Kidney specialist has completed a battery of blood tests and urine analysis (including 24 hr.) No abnormal results arose from all of the tests and protein in urine is less than 6 mg/dl. Ultrasound shows one simple cyst but no other abnormalities. I have no physical symptoms. And no swollen lymph-nodes or swollen ankles etc., Kidney specialist says that kidney biopsy is the only option to give more information. Are there any other alternative tests that could be done? Many thanks!

A kidney biopsy would seem reasonable in your case. Most cases of kidney disease associated with HIV (+) status are associated with protein in the urine. You mention that your urinary protein is normal. It might be possible that your … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Exercise, GFR, Kidney Biopsy, Kidney-Related Health Questions, Medication and Kidney Disease

Sir, what analgesic we want to use in PKD? And what is treatment of PKD?

Polycystic kidney disease (PCKD) is a genetic disease of the kidneys (you are born with the disease). Any medication that you take for pain (analgesic medication) should be discussed with your doctor who knows your medical history and can determine … Continue reading

Posted in Ask the Doctor, Kidney-Related Health Questions, Medication and Kidney Disease

What hypertension drugs do not raise creatinine levels? I have been diagnosed with PKD. My creatinine level is 1.71, I want to know if Ramipril could be causing it? If it is, what drug can I take that will not raise the creatinine level?

This is a complicated question and I will try to answer in a way that makes sense. The way that drugs protect the kidney and help to sustain the kidneys for longer periods of time, is to lower pressures inside … Continue reading

Posted in Ask the Doctor, GFR, Kidney-Related Health Questions, Medication and Kidney Disease, Serum Creatinine

I cannot get an answer as to why someone with end stage renal disease would be prescribed a blood thinner Heparin drip in the hospital which causes over load of fluid for a hemodialysis patient? Also when the Heparin drip was stopped because the 2 blood draws showed the dosage was too high—the blood would not go through the dialysis machine for a 6 hour dialysis treatment

Heparin is the standard blood thinner that is used in dialysis patients.  Heparin is used in almost all dialysis treatments in the United States and is the safest blood thinner to be used in patients who are hospitalized.  I suggest … Continue reading

Posted in Ask the Doctor, Dialysis, Kidney-Related Health Questions, Medication and Kidney Disease, Symptoms and Side Effects, Treatments

Dr. Spry, I’m 68, female, being treated for high cholesterol for past 15 years. Have blood work every 3 months in order to renew simvastatin Rx. After last blood work, my Dr. said my potassium and sodium were high and I should reduce salt, potassium, use of NSAIDS (rarely, maybe once a month), and that my fasting glucose was high (112). I went home and looked over my blood results, compared them to my last 2 years of tests and was shocked to read that the “review” comments on my last 2 sets of tests said I was in CKD stage 3A. I went back to Dr. to discuss this as she has never even mentioned the word “kidney” to me. She was irritated that I came back and said I was fine. She said she is not concerned at all about my kidney function, that it is normal for my age. In April 2016 I started taking Lisinopril for high BP, at that time my eGFR was 76, in July 2016 it was 62, October 2016: 61, April 2017: 54, and in July 2017: 52. My BP now is below 120/80 since taking 10mg Lisinopril daily. I’ve never had a urinalysis. Potassium is 5.7, Sodium 146, Creatinine 1.10, bun/creatinine ratio 17. I am trying to track daily sodium and potassium intake. At this last appt with my Dr., she also took me off simvastatin because my good cholesterol is high. LDL: 106, HDL: 91, Trig:83, total: 214 (with the simvastatin). My question to you is, should I be looking for a new doctor? I am not comfortable with her never mentioning to me the 20 point drop in eGFR from April 2016 to April 2017 and her statement that my kidney function was perfectly normal for my age of 68. But then, I have anxiety issues!

I do recommend that you have a urine test for blood, protein and infection.  This should be done on all patients who have early detected chronic kidney disease (CKD).  Since your estimated glomerular filtration rate (eGFR) is less than 60 … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, Diabetes, GFR, Hypertension/High Blood Pressure, Kidney-Related Health Questions, Laboratory Testing, Medication and Kidney Disease, Symptoms and Side Effects, Treatments

I was diagnosed with Type III collagenofibrotic glomerulopathy in March 2015. My GFR is stage 3B, hovering around 33%. This past week I was diagnosed with multiple myeloma or MGUS [bone marrow biopsy approval pending with insurance company]. My current medications are Benazepril hcl 10mg, Allopurinol 100 mg, Verapamil ER 120mg. Will any medication for the myeloma be counterproductive to the kidney disease?

I cannot anticipate what treatment will be recommended for multiple myeloma.  There are a number of treatments that are used.  Untreated multiple myeloma can injure kidneys and make underlying kidney disease worse, hence, I recommend that you wait for a … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, GFR, Insurance & Medicare Coverage, Kidney-Related Health Questions, Laboratory Testing, Medication and Kidney Disease, Medication and Kidney Function, Symptoms and Side Effects, Treatments

My GFR test is as follows. 2013/60 – 2014/58 – 2015/60 – 2016 – 53 – 2017/44.8. I have been on Protonix and or a generic version of it (Omeprazole) for many years.. Probably 20 or more. Am I in trouble?

I am unable to make a specific diagnosis about your kidney disease based on the information that you share.  I recommend that you discuss your concerns with your primary care physician (PCP).  It is true that in some cases, medications … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, Kidney-Related Health Questions, Laboratory Testing, Medication and Kidney Disease, Medication and Kidney Function, Symptoms and Side Effects, Treatments

Recently diagnosed with CKD stage 3B. Also rheumatoid arthritis diagnosis recently. Is methotrexate safe for me to take?

The dose of Methotrexate must be monitored and sometimes reduced for patients with chronic kidney disease (CKD).  I suggest that you review your concerns with your Rheumatologist and your primary care physician (PCP).  

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, Kidney-Related Health Questions, Laboratory Testing, Medication and Kidney Disease, Symptoms and Side Effects

My twin sister and I have to to get a MRI or a CT scan to check our aorta every year or two. My sister had a MRI with contrast a year ago and the following day her right leg swelled up and it has continued and is now getting worse around her knee. I had a CT with contrast done a few weeks ago and I had bad pain in my back on the left side. Are we having issues with our kidneys. My sister has gone to emergency room but they don’ t seem to be looking at the kidney. And this all started after the MRI.

I am unable to diagnose any form of kidney disease based on the information that you present.  Magnetic resonance Imaging (MRI) contrast is not known to be toxic to the kidneys, although contrast used for computerized tomography (CT) scanning can … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Kidney-Related Health Questions, Laboratory Testing, Medication and Kidney Disease, Medication and Kidney Function, Symptoms and Side Effects, Treatments