Category Archives: Nephrotic Syndrome

My son, 31 years old, has been diagnosed with membranous nephropathy in June. He had PE which he still has some clots. The doctors have him on an auto immune suppression drug and a steroid, which lowers his immune system and has had bouts with cellulitis in the last 5 weeks. Right now he is in the hospital with cellulitis. They have taken him off his diuretic and one of the antibiotics because of the damage it is doing to the kidneys. I’m at a loss. Do you have any insight about this and what can be done for him?

Membranous nephropathy (membranous glomerulonephritis) is a kidney disease that causes significant losses of protein into the urine (proteinuria) that leads to nephrotic syndrome. The nephrotic syndrome leads to fluid retention in the body with prominent swelling that results in swollen … Continue reading

Posted in Ask the Doctor, Kidney-Related Health Questions, Nephrotic Syndrome, Proteinuria

Hello Doctor, The problem I am mentioning here is for my father. He is 62 years old and has both high blood pressure and diabetics. For the past couple of years, he is noticing foamy and bubbly urine and reached out to many hospitals in Hyderabad, India and went through many tests. All the tests showed he had protein loss, however all the doctors asked him to ignore it. For last 1 year, we are seeing increase of protein in his urine and he went to 24 hours urine examination test and results are shockingly high. Can you please help me with how to move forward with this? Test results : Urinary Protein show as 3780 Creatinine shows as 1148 Urine volume 2800 Protien / Creatinine ratio 3.29 Thank you!

The problem you are describing is one of protein in the urine (proteinuria) that is known as nephrotic syndrome. In most cases, the only way to make a specific diagnosis is to perform a kidney biopsy. There are many causes … Continue reading

Posted in Ask the Doctor, Kidney Biopsy, Kidney-Related Health Questions, Nephrotic Syndrome, Proteinuria

Hello Doctor, My father who is 73 years old is suffering from Nephrotic syndrome since July 2017. He has swollen ankles, pitting edema till the knees, mild pleural effusion 5cc. In the latest Urine report : RBC- 0-1 and granular casts are reported. The output is around 50-60% with half Lasix tablet and without lasix is 40-50%. GFR is 53% creatinine is 1.3 earlier (in July 2017) GFR was 64% and creatinine was 1.13, and only proteinuria was the problem. We had to start ACE inhibitor, due to which creatinine and GFR mildly increased. Now only diuretic is going on. He also has myelofibrosis. WBC – 13.70, while platelets are normal. I would like to know whether Myelofibrosis can be the underlying cause of Nephrotic syndrome. The kappa and Lamba light chain in urine both are High. Kappa – 83.60- Ref range.

I am unable to make a specific diagnosis based on the information that you present. Nephrotic syndrome can have many causes and the best way to make a specific diagnosis is to perform a kidney biopsy. Myelofibrosis is a disease … Continue reading

Posted in Ask the Doctor, Kidney Biopsy, Kidney-Related Health Questions, Nephrologist, Nephrotic Syndrome

In both kidneys, mild increased cortical echogenicity with nephropathy. What it mean?

The report likely comes from a ultrasound examination of the kidneys. The quotation that you provide suggests that there is scarring of the kidneys but does not state why this may be occurring.  I suggest that you discuss this with … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, Kidney-Related Health Questions, Laboratory Testing, Nephrotic Syndrome, Treatments

Respected doctor, I’m from India. My age is 23 years. I’m suffering from nephrotic syndrome. The nephrologist doctor said to me that they have to perform renal/kidney biopsy test before any treatment. So my question is… 1. Is that biopsy test is safe? 2. After biopsy test…will the treatment can cure the kidney disease? 3. Is that any kind of side effects of biopsy? Or after biopsy test treatment?

A kidney biopsy will yield a specific diagnosis which will then result in specific treatment.  It is not possible to predict a cure of the kidney disease, but specific diagnosis will result in more specific treatment options that must be … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, Kidney Biopsy, Kidney-Related Health Questions, Laboratory Testing, Nephrotic Syndrome, Treatments

Dear Doctor, My father (Age 67) is losing lot of protein through urine. He was suspected for Multiple Myeloma but his PET scan and bone marrow biopsy reports were absolutely normal. But the protein loss is still going on and that is causing him lot of weakness. We did his Kidney Functioning Test but that showed nothing serious. He was admitted to ICU because of some urine infection during which lot of water was accumulated in his body. He had swelling on his whole body which now is going away through diuretic medicines prescribed by his cardiologist. Is this related to Kidney or Blood?

Protein in the urine (known as proteinuria) is a finding in kidney disease.  It is first necessary to find out exactly how much protein is spilling into the urine.  If that protein loss is more than 3 grams per day, … Continue reading

Posted in Ask the Doctor, Kidney Biopsy, Kidney-Related Health Questions, Laboratory Testing, Nephrologist, Nephrotic Syndrome, Symptoms and Side Effects, Treatments

My son is 2.5 years old and we are in Romania. I am American and my husband is British. My son is being treated here for Nephrotic Syndrome but we would like to take him to England or America for further treatment. Do you have advice about traveling by plane. Perhaps you need to know more about his condition but if you have general advice it would still be helpful.

Traveling by airplane should not pose a risk to anyone with nephrotic syndrome.  The long travel time in an airplane with inactivity could result in blood clots in the legs.  Forming blood clots in the legs of patients with chronic … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, Kidney-Related Health Questions, Laboratory Testing, Nephrotic Syndrome, Pediatric Issues

I have been diagnosed with Minimal change disorder at 39. Back in late October 2016, started having the symptoms, fluid retention in the lower extremities, foam in the urine, etc. My PCP was doing nothing but pill after pill until finally I went to the hospital. Blood tests, urine samples, hospital stay and kidney biopsy all came back with Nephrotic Syndrome, MCD. I am on steroid therapy, which is working. No auto immune disorder can be tied to my condition. No family history either. I have read up that in adults, an allergic reaction could cause MCD. I have asked my Nephrologist if running blood allergy tests could help narrow down the cause so I have something to work with after remission but he doesn’t think it would do any good. What are your thoughts and should I seek a second opinion? Thank you for any insight you give me.

Minimal Change Disease (MCD) also called “nil” disease is a common cause of sudden nephrotic syndrome and will cause sudden swelling with loss of protein in the urine (proteinuria).  The cause has never been determined.  It is thought to be … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, Kidney-Related Health Questions, Laboratory Testing, Minimal Change Disease, Nephrotic Syndrome, Treatments

Is there a need for long term steroid use in nephrotic syndrome? What causes a flare up? Are there any specialists or recommendations for treatment?

There are many causes of nephrotic syndrome.  In most cases, a kidney biopsy is needed to make a specific diagnosis and this leads to specific treatment of the nephrotic syndrome.  You can read about nephrotic syndrome on our web site … Continue reading

Posted in Ask the Doctor, Kidney Biopsy, Kidney-Related Health Questions, Nephrologist, Nephrotic Syndrome, Treatments

My kid has Nephrotic Syndrome. Initially he got it at 3 years of age and later on wards every 14 months he relapses. Now his age is 6 running. Is there any other treatment?

There are a number of treatments for nephrotic syndrome, but in cases of recurrent relapse of the disease in children, it is often necessary to perform a kidney biopsy in order to know the exact disease that is being treated, … Continue reading

Posted in Ask the Doctor, Kidney Biopsy, Kidney-Related Health Questions, Laboratory Testing, Nephrotic Syndrome, Pediatric Issues, Symptoms and Side Effects