Category Archives: Nephrotic Syndrome

I had NS 3 years old and relapse again at age of 20 years (during the relapse a biopsy was performed and MCD is confirmed). I was treated with prednisolone. Now I am 26 years. In six months 3 relapses continuously occur. l take MMF and Wysolone 10 mg alternate day two week. My urine albumin is faint trace. 1. Is remission is occur? 2. What are the after effects?

The clinical course that you describe is of relapsing nephrotic syndrome (NS). Your biopsy indicates that this is caused by Minimal Change Disease (MCD). If your urine protein (albumin) is undetectable, then it would appear that you are in a … Continue reading

Posted in Ask the Doctor, Kidney-Related Health Questions, Minimal Change Disease, Nephrotic Syndrome

My 37 year old cousin has nephrotic syndrome. He has been on medicines since an year. He was improving until last month. However, since last week he is spilling protein again. This is his third relapse in 6 months. He is on predinisolone. The doctor has asked to get a kidney biopsy done. Is there any other way that he can be treated? Also, until when should he be given steroids? I would appreciate your guidance on this.

I would agree that a kidney biopsy is indicated once he has suffered his third relapse. The kidney biopsy will yield a specific diagnosis and this will lead to more specific prognosis and specific treatment. There are many causes of … Continue reading

Posted in Ask the Doctor, Kidney Biopsy, Kidney-Related Health Questions, Nephrotic Syndrome

Hi, I noticed bubbles in my urine in early April. I saw a doctor in mid April and have since found out that I have eGFR of 38. I had a 24 hour urine test done and my total protein was 7630. I have none of the typical pre-existing conditions – e.g. no diabetes, normal blood pressure. Other tests showed a very high level of inflammation and somewhat anemic. Neither my GP nor my nephrologist seems particularly concerned about my high protein. I have a kidney biopsy scheduled for next Thursday, and it will take another week before we get any results. I’m guessing nothing will happen for another month. I am very anxious that so much time is transpiring with such high protein in my urine and no treatment. It has been two months already. Does another month matter? Thank you.

The amount of protein in your urine is quite high. This amount is known as nephrotic range proteinuria. Any amount of protein that is greater than 3500 milligrams of protein per day is nephrotic range proteinuria. In this case, the … Continue reading

Posted in Ask the Doctor, Hypertension/High Blood Pressure, Kidney Biopsy, Kidney-Related Health Questions, Nephrotic Syndrome

My son is 13. He is on blood pressure medications for a week now. His blood pressure is over 130. What should his blood pressure be while his nephrotic syndrome is active?

This question must be answered by your son’s pediatric nephrologist.  I am an adult nephrologist and do not regularly treat children with nephrotic syndrome.  You son’s pediatric nephrologist should be able to provide proper parameters for control of your son’s … Continue reading

Posted in Ask the Doctor, Hypertension/High Blood Pressure, Kidney-Related Health Questions, Nephrotic Syndrome, Pediatric Issues

My son, 31 years old, has been diagnosed with membranous nephropathy in June. He had PE which he still has some clots. The doctors have him on an auto immune suppression drug and a steroid, which lowers his immune system and has had bouts with cellulitis in the last 5 weeks. Right now he is in the hospital with cellulitis. They have taken him off his diuretic and one of the antibiotics because of the damage it is doing to the kidneys. I’m at a loss. Do you have any insight about this and what can be done for him?

Membranous nephropathy (membranous glomerulonephritis) is a kidney disease that causes significant losses of protein into the urine (proteinuria) that leads to nephrotic syndrome. The nephrotic syndrome leads to fluid retention in the body with prominent swelling that results in swollen … Continue reading

Posted in Ask the Doctor, Kidney-Related Health Questions, Nephrotic Syndrome, Proteinuria

Hello Doctor, The problem I am mentioning here is for my father. He is 62 years old and has both high blood pressure and diabetics. For the past couple of years, he is noticing foamy and bubbly urine and reached out to many hospitals in Hyderabad, India and went through many tests. All the tests showed he had protein loss, however all the doctors asked him to ignore it. For last 1 year, we are seeing increase of protein in his urine and he went to 24 hours urine examination test and results are shockingly high. Can you please help me with how to move forward with this? Test results : Urinary Protein show as 3780 Creatinine shows as 1148 Urine volume 2800 Protien / Creatinine ratio 3.29 Thank you!

The problem you are describing is one of protein in the urine (proteinuria) that is known as nephrotic syndrome. In most cases, the only way to make a specific diagnosis is to perform a kidney biopsy. There are many causes … Continue reading

Posted in Ask the Doctor, Kidney Biopsy, Kidney-Related Health Questions, Nephrotic Syndrome, Proteinuria

Hello Doctor, My father who is 73 years old is suffering from Nephrotic syndrome since July 2017. He has swollen ankles, pitting edema till the knees, mild pleural effusion 5cc. In the latest Urine report : RBC- 0-1 and granular casts are reported. The output is around 50-60% with half Lasix tablet and without lasix is 40-50%. GFR is 53% creatinine is 1.3 earlier (in July 2017) GFR was 64% and creatinine was 1.13, and only proteinuria was the problem. We had to start ACE inhibitor, due to which creatinine and GFR mildly increased. Now only diuretic is going on. He also has myelofibrosis. WBC – 13.70, while platelets are normal. I would like to know whether Myelofibrosis can be the underlying cause of Nephrotic syndrome. The kappa and Lamba light chain in urine both are High. Kappa – 83.60- Ref range.

I am unable to make a specific diagnosis based on the information that you present. Nephrotic syndrome can have many causes and the best way to make a specific diagnosis is to perform a kidney biopsy. Myelofibrosis is a disease … Continue reading

Posted in Ask the Doctor, Kidney Biopsy, Kidney-Related Health Questions, Nephrologist, Nephrotic Syndrome

In both kidneys, mild increased cortical echogenicity with nephropathy. What it mean?

The report likely comes from a ultrasound examination of the kidneys. The quotation that you provide suggests that there is scarring of the kidneys but does not state why this may be occurring.  I suggest that you discuss this with … Continue reading

Posted in Ask the Doctor, Blood/Urine Testing For Kidney Disease, Chronic Kidney Disease, Kidney-Related Health Questions, Laboratory Testing, Nephrotic Syndrome, Treatments

Respected doctor, I’m from India. My age is 23 years. I’m suffering from nephrotic syndrome. The nephrologist doctor said to me that they have to perform renal/kidney biopsy test before any treatment. So my question is… 1. Is that biopsy test is safe? 2. After biopsy test…will the treatment can cure the kidney disease? 3. Is that any kind of side effects of biopsy? Or after biopsy test treatment?

A kidney biopsy will yield a specific diagnosis which will then result in specific treatment.  It is not possible to predict a cure of the kidney disease, but specific diagnosis will result in more specific treatment options that must be … Continue reading

Posted in Ask the Doctor, Chronic Kidney Disease, Kidney Biopsy, Kidney-Related Health Questions, Laboratory Testing, Nephrotic Syndrome, Treatments

Dear Doctor, My father (Age 67) is losing lot of protein through urine. He was suspected for Multiple Myeloma but his PET scan and bone marrow biopsy reports were absolutely normal. But the protein loss is still going on and that is causing him lot of weakness. We did his Kidney Functioning Test but that showed nothing serious. He was admitted to ICU because of some urine infection during which lot of water was accumulated in his body. He had swelling on his whole body which now is going away through diuretic medicines prescribed by his cardiologist. Is this related to Kidney or Blood?

Protein in the urine (known as proteinuria) is a finding in kidney disease.  It is first necessary to find out exactly how much protein is spilling into the urine.  If that protein loss is more than 3 grams per day, … Continue reading

Posted in Ask the Doctor, Kidney Biopsy, Kidney-Related Health Questions, Laboratory Testing, Nephrologist, Nephrotic Syndrome, Symptoms and Side Effects, Treatments